{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:56:14Z","timestamp":1789660574883,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Sedentary behavior (SB) may affect arterial stiffness, preceding the development of cardiovascular disease. We investigated the association of objectively measured SB with arterial stiffness. We also investigated factors that affected this association. We recruited adult volunteers and measured SB with thigh\u2010worn accelerometery for 24\u2009hrs\/day for eight consecutive days. Central (carotid\u2010femoral pulse wave velocity, cfPWV, gold standard) and local carotid arterial stiffness (stiffness index Beta and pressure\u2010strain elasticity E<jats:sub>P<\/jats:sub>) were measured with ultrasound. Linear regression was used and adjusted for demographics, cardiometabolic factors, and moderate\u2010to\u2010vigorous physical activity (MVPA) volume. Effect modification was studied with interaction terms. Participants (<jats:italic>N<\/jats:italic>\u2009=\u2009664, 64 (standard deviation: 11, range: 23\u201389) years, 397 (59.8%) male) demonstrated 9.1 (1.6) hrs\/day of SB, and arterial stiffness was 8.6 (3.0) m\/s for cfPWV, 6.4 (2.9) for Beta, and 87 (43) kPa for E<jats:sub>P<\/jats:sub>. SB was not associated with cfPWV (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.04 95% CI (\u22120.11, 0.18), <jats:italic>p<\/jats:italic>\u2009=\u20090.60). The association of SB with local arterial stiffness was modified by systolic blood pressure (SBP) and MVPA volume. Stratified analyses revealed positive associations of SB with Beta (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.29 (0.05, 0.53), <jats:italic>p<\/jats:italic>\u2009=\u20090.016) and E<jats:sub>P<\/jats:sub> (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20094.83 (1.39, 8.27), <jats:italic>p<\/jats:italic>\u2009=\u20090.006) in participants with SBP &gt;\u2009134\u2009mmHg or\u2009&gt;\u2009103\u2009min\/day of MVPA (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.23 (0.03, 0.42), <jats:italic>p<\/jats:italic>\u2009=\u20090.024 and <jats:italic>\u03b2<\/jats:italic>\u2009=\u20093.55 (0.82, 6.29), <jats:italic>p<\/jats:italic>\u2009=\u20090.011, respectively). We found no association of objectively measured SB with central arterial stiffness. However, SB was positively associated with local carotid stiffness in participants with higher SBP or MVPA levels. In certain subgroups, SB may affect carotid arterial stiffening, reinforcing the relation between SB and cardiovascular disease.<\/jats:p>","DOI":"10.1111\/sms.14757","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T08:20:13Z","timestamp":1730881213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of Objectively Measured Sedentary Behavior With Arterial Stiffness: Findings From the Nijmegen Exercise Study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6330-4157","authenticated-orcid":false,"given":"Koen\u00a0M.","family":"van der Sluijs","sequence":"first","affiliation":[{"name":"Department of Medical BioSiences Radboud University Medical Center  Nijmegen The 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