{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:13:15Z","timestamp":1790928795862,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The combination of maximal oxygen uptake (V\u0307O\n                    <jats:sub>2<\/jats:sub>\n                    max), fractional utilization at lactate threshold (FU\n                    <jats:sub>LT<\/jats:sub>\n                    ), and running economy (RE) is considered to largely determine\/predict marathon performance, which is also closely associated with the speed at lactate threshold (sLT). Although these determinants are considered to deteriorate during prolonged running, except for RE, their temporal changes with fatigue remain largely unknown. This study aimed to measure the changes in V\u0307O\n                    <jats:sub>2<\/jats:sub>\n                    max, FU\n                    <jats:sub>LT<\/jats:sub>\n                    , RE, and sLT after running for 90 and 120\u2009min in the heavy\u2010intensity domain. Fourteen trained marathon runners (V\u0307O\n                    <jats:sub>2<\/jats:sub>\n                    max 63.1\u2009\u00b1\u20095.8\u2009mL\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ; marathon time 2:46:58\u2009h:mm:ss) completed three separate visits to determine sLT, FU\n                    <jats:sub>LT<\/jats:sub>\n                    , and V\u0307O\n                    <jats:sub>2<\/jats:sub>\n                    peak in the following conditions (sessions): unfatigued, and after two prolonged runs of 90 and 120\u2009min at a fixed speed (10% \u0394 between LT and lactate threshold 2). During the runs, respiratory gases were collected at 15\u2009min intervals to quantify RE. Decreases in V\u0307O\n                    <jats:sub>2<\/jats:sub>\n                    peak (\u22123.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04 [post\u201090]; \u22127.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001 [post\u2010120]) and subsequent increases in FU\n                    <jats:sub>LT<\/jats:sub>\n                    (+2.8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03 [post\u201090]; +4.9%\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01 [post\u2010120]) both occurred at an increasing rate with run duration, with FU\n                    <jats:sub>LT<\/jats:sub>\n                    changes linked to the decreased V\u0307O\n                    <jats:sub>2<\/jats:sub>\n                    peak, while RE (mL\u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7km\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) deteriorated more linearly with time (by 4.2% [post\u201090] and 5.8% [post\u2010120],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). sLT also showed a nonlinear decrease, from 14.0 to 13.5 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01 post\u201090), to 13.0\u2009km\u00b7h\n                    <jats:sup>\u22121<\/jats:sup>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001 post\u2010120). In conclusion, performance determinants and sLT changed following 90\u2009min, and particularly 120\u2009min of prolonged running. These dynamic changes have strong implications for running performance and would particularly affect longer duration events such as the marathon.\n                  <\/jats:p>","DOI":"10.1111\/sms.70076","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T01:40:39Z","timestamp":1747359639000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The Effect of 90 and 120\u2009Min of Running on the Determinants of Endurance Performance in Well\u2010Trained Male Marathon Runners"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8148-8843","authenticated-orcid":false,"given":"Michele","family":"Zanini","sequence":"first","affiliation":[{"name":"School of Sport, Exercise, and Health Sciences Loughborough University  Loughborough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Folland","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise, and Health Sciences Loughborough University  Loughborough UK"},{"name":"National Institute for Health and Care Research (NIHR), Leicester Biomedical Research Centre  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Blagrove","sequence":"additional","affiliation":[{"name":"School of Sport, Exercise, and Health Sciences Loughborough University  Loughborough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.70.2.683"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00647.2020"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1260\/174795406777641258"},{"key":"e_1_2_11_5_1","first-page":"1","article-title":"The Fourth Dimension: Physiological Resilience as an Independent Determinant of Endurance Exercise Performance","volume":"1","author":"Jones A. 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C.Blagrove \u201cStrength Training Improves Running Economy Durability and Fatigued High\u2010Intensity Performance in Well\u2010Trained Male Runners: A Randomized Control Trial \u201dMedicine and Science in Sports and Exercise (2025).","DOI":"10.1249\/MSS.0000000000003685"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2009.01035.x"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12990"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1123\/ijsnem.2019-0004"}],"container-title":["Scandinavian Journal of Medicine &amp; Science in Sports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sms.70076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T07:56:20Z","timestamp":1747814180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sms.70076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/sms.70076"],"URL":"https:\/\/doi.org\/10.1111\/sms.70076","archive":["Portico"],"relation":{},"ISSN":["0905-7188","1600-0838"],"issn-type":[{"value":"0905-7188","type":"print"},{"value":"1600-0838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70076"}}