{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:52:55Z","timestamp":1787064775425,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To explore the benefits and safety of supervised and unsupervised exercise among localized and metastatic prostate cancer patients (PCa) during long\u2010term androgen deprivation therapy (ADT). A total of 44 PCa patients were enrolled in this randomized controlled trial (RCT). Participants were randomized in a 1:1 ratio into the supervised exercise sessions group or the unsupervised home\u2010based exercise group for three months. The primary outcomes assessed included quality of life (QoL), body composition, and metabolic markers, which were measured at baseline, after 3\u2009months, and at 6\u2009months. Muscle strength was evaluated exclusively in the supervised exercise group. The main statistical models used were the Mann\u2013Whitney\n                    <jats:italic>U<\/jats:italic>\n                    \u2010test for between\u2010group comparisons and the Wilcoxon rank\u2010sum test for within\u2010group changes. No adverse events were reported during the exercise period. There were no significant differences in QoL, body composition, or metabolic profiles between the intervention and control groups. The supervised exercise group demonstrated significant improvement in emotional functioning (\n                    <jats:italic>Z<\/jats:italic>\n                    \u2009=\u2009\u22122.102,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.036) and all exercise performance metrics (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), with the most pronounced gains observed in the leg press (\n                    <jats:italic>Z<\/jats:italic>\n                    \u2009=\u2009\u22124.17,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Furthermore, a significant association was identified between strength improvements and enhanced self\u2010evaluated physical function (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Supervised exercise is safe for patients with localized and metastatic PCa undergoing ADT and leads to significant improvements in emotional well\u2010being and muscle strength, which translate to better self\u2010reported physical function. Findings underscore the need for RCTs with longer intervention and follow\u2010up periods on supervised exercise, especially in metastatic PCa patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    identifier: #NCT04050397\n                  <\/jats:p>","DOI":"10.1111\/sms.70084","type":"journal-article","created":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T06:24:45Z","timestamp":1749277485000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Is Exercise During Androgen Deprivation Therapy Effective and Safe? A Randomized Controlled Trial"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2264-0020","authenticated-orcid":false,"given":"Lauri","family":"Rantaniemi","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Technology Tampere University  Tampere Finland"},{"name":"Kanta\u2010H\u00e4me Central Hospital  H\u00e4meenlinna Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9221-3279","authenticated-orcid":false,"given":"Ilkka","family":"Jussila","sequence":"additional","affiliation":[{"name":"Wellbeing Services County of Central Finland  Jyv\u00e4skyl\u00e4 Finland"},{"name":"Faculty of Sport and Health Sciences University of Jyv\u00e4skyl\u00e4  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7814-427X","authenticated-orcid":false,"given":"Aino","family":"Siltari","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology Tampere University  Tampere Finland"},{"name":"Department of Pharmacology, Faculty of Medicine University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2305-4741","authenticated-orcid":false,"given":"Juha P.","family":"Ahtiainen","sequence":"additional","affiliation":[{"name":"Faculty of Sport and Health Sciences University of Jyv\u00e4skyl\u00e4  Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9554-0784","authenticated-orcid":false,"given":"Annastiina","family":"Hakulinen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology Tampere University  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eeva","family":"Harju","sequence":"additional","affiliation":[{"name":"TAYS Cancer Center Tampere University Hospital  Tampere Finland"},{"name":"Department of Gastroenterology Tampere University Hospital, Wellbeing Services County of Pirkanmaa  Tampere Finland"},{"name":"Department of Surgery Tampere University Hospital, Wellbeing Services County of Pirkanmaa  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1992-1251","authenticated-orcid":false,"given":"Jorma","family":"Sormunen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology Tampere University  Tampere Finland"},{"name":"TAYS Cancer Center Tampere University Hospital  Tampere Finland"},{"name":"Docrates Cancer Center  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tupu","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[{"name":"Varala Sports Institute  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teuvo L. 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