{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:03:57Z","timestamp":1791234237400,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The purpose of this study was to compare quadriceps morphology between legs and individuals with a first\u2010time anterior cruciate ligament (ACL) tear and uninjured controls. This was an exploratory cross\u2010sectional study. We enrolled participants who were aged 19\u201335\u2009years, and 6\u201360\u2009months after a first\u2010time ACL tear as well as uninjured controls. Participants attended two sessions separated by a minimum of 7\u2009days. Bilateral knee extensor concentric and eccentric strength and rate of torque development (RTD) were assessed at the first session, and bilateral vastus lateralis muscle biopsies were obtained at the second. Muscle fiber\u2010type specific cross\u2010sectional area (fCSA), fiber\u2010type proportions, and extracellular matrix area were calculated. Between\u2010limb and between\u2010group differences were estimated using mixed\u2010effects regression. 41 of 47 (87%) participants completed the study (<jats:italic>n<\/jats:italic>\u2009=\u200921 ACL, <jats:italic>n<\/jats:italic>\u2009=\u200920 control). ACL group participants were a median (range) of 23\u2009months from injury, and 78% had undergone an ACL reconstruction. Uninjured group participants had greater knee extensor concentric strength (\u221239.3\u2009Nm; 95% CI: \u221254.2, \u221220.5), eccentric strength (\u221230.2\u2009Nm; 95% CI: \u221253.4, \u221211.6), and RTD (\u22120.16\u2009Nm\/ms; 95% CI: \u22120.33, \u22120.04). No between\u2010group or between\u2010limb differences in muscle fiber\u2010type specific fCSA, fiber\u2010type proportions, or extracellular matrix area were observed. Despite deficits in knee extensor muscle performance, no difference in vastus lateralis fiber\u2010type specific CSA, fiber\u2010type proportion, or extracellular matrix area was detected between individuals 6\u201360\u2009months after an ACL tear and uninjured controls.<\/jats:p>","DOI":"10.1111\/sms.70109","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T08:29:51Z","timestamp":1752913791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quadriceps Morphology 6\u2010 to 60\u2010Months After Anterior Cruciate Ligament Tear"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5135-1191","authenticated-orcid":false,"given":"Justin M.","family":"Losciale","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Faculty of Medicine University of British Columbia  Vancouver Canada"},{"name":"Arthritis Research Canada  Vancouver Canada"},{"name":"Edwin S.H. Leong Centre for Healthy Aging, Faculty of Medicine University of British Columbia  Vancouver Canada"},{"name":"Informatics, Decision\u2010Enhancement and Analytic Sciences (IDEAS) Center of Innovation Veterans Affairs Salt Lake City Health Care System  Salt Lake City Utah USA"},{"name":"Division of Epidemiology, Department of Internal Medicine University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Department of Medical Genetics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-8756","authenticated-orcid":false,"given":"Marine","family":"Theret","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Department of Medical Genetics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6972-404X","authenticated-orcid":false,"given":"Allyson M.","family":"Schweitzer","sequence":"additional","affiliation":[{"name":"School of Kinesiology, Faculty of Education University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0209-0786","authenticated-orcid":false,"given":"Matthew D.","family":"Fliss","sequence":"additional","affiliation":[{"name":"School of Kinesiology, Faculty of Education University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Scarr","sequence":"additional","affiliation":[{"name":"Allan McGavin Sports Medicine Clinic  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2146-538X","authenticated-orcid":false,"given":"Xian He","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Faculty of Medicine University of British Columbia  Vancouver Canada"},{"name":"Arthritis Research Canada  Vancouver Canada"},{"name":"Centre for Aging SMART University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin","family":"Prasad","sequence":"additional","affiliation":[{"name":"Division of Sport and Exercise Medicine, Department of Family Practice University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8648-1591","authenticated-orcid":false,"given":"Michael A.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Faculty of Medicine University of British Columbia  Vancouver Canada"},{"name":"Centre for Aging SMART University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7026-8422","authenticated-orcid":false,"given":"Michael S.","family":"Koehle","sequence":"additional","affiliation":[{"name":"School of Kinesiology, Faculty of Education University of British Columbia  Vancouver Canada"},{"name":"Division of Sport and Exercise Medicine, Department of Family Practice University of British Columbia  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0368-2620","authenticated-orcid":false,"given":"Fabio M. 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