{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:43:24Z","timestamp":1785815004271,"version":"3.56.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Low\u2010volume sprint interval training (LVSIT) increases peak oxygen uptake (VO<jats:sub>2peak<\/jats:sub>) when performed three times a week for 6\u2009weeks. Methodological and statistical concerns, however, constrain the veracity of prior findings. We therefore reassessed the VO<jats:sub>2peak<\/jats:sub> response to LVSIT using a randomized controlled trial design to mitigate bias and augment reporting quality. A generative model of VO<jats:sub>2peak<\/jats:sub> was constructed as a function of group, baseline VO<jats:sub>2peak<\/jats:sub>, age, sex, height, and change in body mass. Simulation experiments using previous data estimated that <jats:italic>n<\/jats:italic>\u2009=\u200915\/group would achieve 80% power to detect a difference of 1 metabolic equivalent (MET) with a credible interval (CrI) of \u2264\u20091\u2010MET. Insufficiently active young adults (22\u2009\u00b1\u20093\u2009years, body mass index: 24\u2009\u00b1\u20094\u2009kg  m<jats:sup>\u22122<\/jats:sup>, baseline VO<jats:sub>2peak<\/jats:sub>: 33\u2009\u00b1\u20097\u2009mL  kg<jats:sup>\u22121<\/jats:sup>  min<jats:sup>\u22121<\/jats:sup>) were randomized to perform 6\u2009weeks of thrice weekly LVSIT (<jats:italic>n<\/jats:italic>\u2009=\u200917) or no exercise (CTL; <jats:italic>n<\/jats:italic>\u2009=\u200920). The LVSIT protocol involved 3\u2009\u00d7\u200920\u2010s \u201call out\u201d sprints over a 10\u2010min session of low\u2010intensity cycling. Bayesian generative multivariate modeling revealed that LVSIT increased absolute [+325\u2009mL  min<jats:sup>\u22121<\/jats:sup> (101\u2013605)] and relative VO<jats:sub>2peak<\/jats:sub> [+5.6\u2009mL  kg<jats:sup>\u22121<\/jats:sup>  min<jats:sup>\u22121<\/jats:sup> (2.2\u20138.1)] versus CTL. All but one LVSIT participant (94%) were deemed a responder (i.e., mean estimate\u2009\u00b1\u200995% CrI for relative VO<jats:sub>2peak<\/jats:sub> &gt;\u20090). In contrast, four CTL participants (20%) met this criterion. LVSIT also improved time to exhaustion by +133\u2009s (101\u2013160) versus CTL. We unequivocally demonstrate that 6\u2009weeks of thrice weekly LVSIT increased VO<jats:sub>2peak<\/jats:sub> in insufficiently active young adults compared to no exercise. By incorporating a robust design that included preregistration, concealed allocation assignment, statistical best practices, and applied Bayesian methods, and open data\u2010sharing, this study addresses prior methodological critiques of similar previous work.<\/jats:p>","DOI":"10.1111\/sms.70130","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:00:57Z","timestamp":1756468857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Six Weeks of Low\u2010Volume Sprint Interval Training Improves Peak Oxygen Uptake Compared to a Non\u2010Exercise Control: A Randomized Controlled Trial"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9934-3835","authenticated-orcid":false,"given":"John R. 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