{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:07:58Z","timestamp":1785892078400,"version":"3.56.0"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","award":["18\u201010\u20100559"],"award-info":[{"award-number":["18\u201010\u20100559"]}],"id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008248","name":"Fonden for Faglig Udvikling af Speciall\u00e6gepraksis","doi-asserted-by":"publisher","award":["A2387"],"award-info":[{"award-number":["A2387"]}],"id":[{"id":"10.13039\/501100008248","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","award":["R181\u2010A6356"],"award-info":[{"award-number":["R181\u2010A6356"]}],"id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005860","name":"Helsefonden","doi-asserted-by":"publisher","award":["20\u2010B\u20100214"],"award-info":[{"award-number":["20\u2010B\u20100214"]}],"id":[{"id":"10.13039\/501100005860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005747","name":"A.P. M\u00f8ller og Hustru Chastine Mc-Kinney M\u00f8llers Fond til almene Formaal","doi-asserted-by":"publisher","award":["20\u2010L\u20100186"],"award-info":[{"award-number":["20\u2010L\u20100186"]}],"id":[{"id":"10.13039\/501100005747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Standard rehabilitation for knee osteoarthritis (knee\u2010OA) combines patient education and neuromuscular exercises (NEMEX). Heavy\u2010load resistance training (HLRT) has shown positive effects on pain, functionality, and muscle mass, but can be painful with knee\u2010OA. Low\u2010load blood\u2010flow restricted resistance exercise (BFR\u2010RE) has shown comparable effects to HLRT without promoting exercise\u2010induced pain. Therefore, the present study examined the effect of BFR\u2010RE vs. NEMEX on self\u2010perceived knee pain, functional performance, and pain sensitization in knee\u2010OA individuals. Ninety\u2010six participants (age 56.7\u2009\u00b1\u20097.6; 49 females, 47 males) with symptomatic knee\u2010OA were randomized to 12\u2009weeks biweekly BFR\u2010RE or NEMEX. BFR\u2010RE was performed at 60%\u201380% of total arterial occlusion pressure. Control participants completed a 12\u2010week NEMEX program. Both groups also attended patient education.\n                    <jats:italic>Primary outcome<\/jats:italic>\n                    : Change in the Knee injury and Osteoarthritis Outcome Score (KOOS) pain subscale from baseline to 12\u2009weeks.\n                    <jats:italic>Secondary outcomes<\/jats:italic>\n                    : Remaining KOOS subscales, Oxford Knee Score (OKS), 30\u2010s sit\u2010to\u2010stand (STS), STS power, 4 \u00d7\u200910 m fast\u2010paced walking (4 \u00d7\u200910 m\u2010FWT), stair climb test (SCT), spreading and local pain sensitization measured as pressure pain thresholds (PPT). No significant between\u2010group difference in the change in KOOS\u2010Pain was observed (+6.4 points, 95% CI\u2009=\u2009\u22121.0\u201313.7, effect size (ES)\u2009=\u20090.35,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.07) or the remaining KOOS subscales and OKS (ES\u2009=\u20090.05\u20130.20,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). BFR\u2010RE demonstrated greater improvements than NEMEX for all functional outcomes (STS, STS power, 4 \u00d7\u200910 m FWT, SCT) (ES\u2009=\u20090.89\u20131.56,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and spreading sensitization (ES\u2009=\u20090.43\u20130.55,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). BFR\u2010RE and NEMEX were equally effective in reducing knee pain, while BFR\u2010RE achieved greater statistical gains in functional performance and improved spreading sensitization in persons with moderate knee\u2010OA. The enhanced improvements with BFR\u2010RE compared to NEMEX represent novel insights that should be considered in future treatments of knee\u2010OA.\n                  <\/jats:p>","DOI":"10.1111\/sms.70154","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T06:50:13Z","timestamp":1760683813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Blood\u2010Flow Restricted Resistance Exercise Versus Neuromuscular Exercise on Self\u2010Perceived Knee Pain, Function, Quality of Life, and Objective Measures of Functional Performance and Pain Sensitization in Adults With Knee Osteoarthritis\u2014A Randomized Controlled Trial"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3322-6044","authenticated-orcid":false,"given":"Brian","family":"S\u00f8rensen","sequence":"first","affiliation":[{"name":"Department of Sports Science and Clinical Biomechanics University of Southern Denmark  Odense M Denmark"},{"name":"Institute of Sports Medicine Copenhagen (ISMC), Department of Orthopaedic Surgery Copenhagen University Hospital Bispebjerg\u2010Frederiksberg  Copenhagen Denmark"},{"name":"Department of Physical &amp; Occupational Therapy Copenhagen University Hospital Bispebjerg\u2010Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4308-5484","authenticated-orcid":false,"given":"S. Peter","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Institute of Sports Medicine Copenhagen (ISMC), Department of Orthopaedic Surgery Copenhagen University Hospital Bispebjerg\u2010Frederiksberg  Copenhagen Denmark"},{"name":"Department of Physical &amp; Occupational Therapy Copenhagen University Hospital Bispebjerg\u2010Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9773-7361","authenticated-orcid":false,"given":"Per","family":"Aagaard","sequence":"additional","affiliation":[{"name":"Department of Sports Science and Clinical Biomechanics University of Southern Denmark  Odense M Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1607-5379","authenticated-orcid":false,"given":"Rene B.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Institute of Sports Medicine Copenhagen (ISMC), Department of Orthopaedic Surgery Copenhagen University Hospital Bispebjerg\u2010Frederiksberg  Copenhagen Denmark"},{"name":"Center for Fast Ultrasound Imaging, Department of Health Technology Technical University of Denmark  Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-9152","authenticated-orcid":false,"given":"Mikkel H.","family":"Hjortshoej","sequence":"additional","affiliation":[{"name":"Institute of Sports Medicine Copenhagen (ISMC), Department of Orthopaedic Surgery Copenhagen University Hospital Bispebjerg\u2010Frederiksberg  Copenhagen Denmark"},{"name":"Department of Physical &amp; Occupational Therapy Copenhagen University Hospital Bispebjerg\u2010Frederiksberg  Copenhagen Denmark"},{"name":"Centre for Health and Rehabilitation University College Absalon  Slagelse Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0594-3553","authenticated-orcid":false,"given":"Sofie K.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Geriatric Research Unit, Department of Geriatric and Palliative Medicine Copenhagen University Hospital Bispebjerg\u2010Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8063-6508","authenticated-orcid":false,"given":"Charlotte","family":"Suetta","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Geriatric Research Unit, Department of Geriatric and Palliative Medicine Copenhagen University Hospital Bispebjerg\u2010Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1648-5746","authenticated-orcid":false,"given":"Christian","family":"Coupp\u00e9","sequence":"additional","affiliation":[{"name":"Institute of Sports Medicine Copenhagen (ISMC), Department of Orthopaedic Surgery Copenhagen University Hospital Bispebjerg\u2010Frederiksberg  Copenhagen Denmark"},{"name":"Department of Physical &amp; 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