{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:16:45Z","timestamp":1784125005387,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study assessed the safety of percutaneous muscle biopsy by analyzing over 2400 procedures performed between 2007 and 2025 in healthy individuals and patients with chronic diseases. We retrospectively reviewed biopsy\u2010related adverse events among 1246 participants (471 healthy adults and 775 patients) to investigate whether health status or repeated sampling at the same site influenced complication rates. A total of 2435 biopsies were performed, primarily on the vastus lateralis muscle (97%). Overall, 80.6% of the procedures had no adverse events. The most common adverse events were erythema (6.6%), ecchymosis (4.1%), and pain (3.9%). Serious complications, including loss of consciousness (vasovagal syncope), were extremely rare (\u2264\u20090.04%). Most adverse events occurred in isolation (74.9%) and did not preclude participation in subsequent research activities. Repeated biopsies modestly increased the risk of minor adverse events, particularly bleeding, erythema, and bruising. Notably, these were more frequently reported among healthy volunteers than among patients. In conclusion, percutaneous muscle biopsy is a safe and well\u2010tolerated procedure, even when performed repeatedly or in individuals with chronic diseases. The minor adverse events were infrequent, transient, and clinically manageable. These findings support the continued use of this technique in both research and clinical settings.<\/jats:p>","DOI":"10.1111\/sms.70160","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:22:15Z","timestamp":1762201335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety of Percutaneous Muscle Biopsy: An Update Based on Over 2400 Procedures"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3514-558X","authenticated-orcid":false,"given":"Jhonnatan Vasconcelos Pereira","family":"Santos","sequence":"first","affiliation":[{"name":"Applied Physiology and Nutrition Research Group\u2014School of Physical Education and Sport, Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Center of Lifestyle Medicine, Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4281-3427","authenticated-orcid":false,"given":"Andresa Rossilho","family":"Casale","sequence":"additional","affiliation":[{"name":"Applied Physiology and Nutrition Research Group\u2014School of Physical Education and Sport, Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Center of Lifestyle Medicine, Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael de Almeida","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Applied Physiology and Nutrition Research Group\u2014School of Physical Education and Sport, Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Center of Lifestyle Medicine, Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Borelli Garcia Eluf","family":"Politi","sequence":"additional","affiliation":[{"name":"Applied Physiology and Nutrition Research Group\u2014School of Physical Education and Sport, Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Center of Lifestyle Medicine, Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Katsuyuki","family":"Shinjo","sequence":"additional","affiliation":[{"name":"Rheumatology Division, Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9513-6132","authenticated-orcid":false,"given":"Hamilton","family":"Roschel","sequence":"additional","affiliation":[{"name":"Applied Physiology and Nutrition Research Group\u2014School of Physical Education and Sport, Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Center of Lifestyle Medicine, Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Laboratory of Assessment and Conditioning in Rheumatology, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7100-8681","authenticated-orcid":false,"given":"Bruno","family":"Gualano","sequence":"additional","affiliation":[{"name":"Applied Physiology and Nutrition Research Group\u2014School of Physical Education and Sport, Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Center of Lifestyle Medicine, Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Rheumatology Division, Faculdade de Medicina FMUSP Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Laboratory of Assessment and Conditioning in Rheumatology, Hospital das Cl\u00ednicas HCFMUSP, Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"issue":"68","key":"e_1_2_9_2_1","first-page":"511","article-title":"Muscle Electrolytes in Man Determined by Neutron Activation Analysis on Needle Biopsy Specimens","volume":"14","author":"Bergstrom J.","year":"1962","journal-title":"Scandinavian Journal of Clinical & Laboratory 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