{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:42:16Z","timestamp":1780609336058,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007480","name":"Universidad de Castilla-La Mancha","doi-asserted-by":"publisher","award":["2025\u2010GRIN\u201038408"],"award-info":[{"award-number":["2025\u2010GRIN\u201038408"]}],"id":[{"id":"10.13039\/501100007480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007480","name":"Universidad de Castilla-La Mancha","doi-asserted-by":"publisher","award":["2020\u2010PREDUCLM\u201014936"],"award-info":[{"award-number":["2020\u2010PREDUCLM\u201014936"]}],"id":[{"id":"10.13039\/501100007480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to investigate the effect of training intensity on contralateral adaptations following unilateral power\u2010oriented resistance training (PT) in older adults. This secondary analysis of a within\u2010person randomized controlled trial included 45 older adults (\u2265\u200965\u2009years; 25 women). After an 8\u2010week control period (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200945), part of the participants completed 12\u2009weeks of a volume load\u2010matched PT on one lower limb using either light loads (40% 1\u2010RM,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099) or heavy loads (80% 1\u2010RM,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910), while the contralateral limb did not exercise. Unilateral performance was assessed before and after each period through isometric tests (maximal isometric force, rate of force development, and muscle excitation) and dynamic tests (1\u2010RM, maximal muscle power and maximal unloaded velocity determined through a force\u2010velocity relationship test). Additionally, mid\u2010thigh muscle mass and whole\u2010body physical function were assessed. Linear mixed models were conducted to compare the effect (Cohen's\n                    <jats:italic>d<\/jats:italic>\n                    ) of training intensity on the efficacy and magnitude of the contralateral adaptations and their impact on physical function. No contralateral adaptations were observed in any of the isometric tests. In contrast, untrained limbs showed comparable improvements in 1\u2010RM (\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.35\u20130.42;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.001) and maximal muscle power (\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.49\u20130.54;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.001) regardless of PT intensity. Only heavy\u2010load PT improved maximal unloaded velocity in the contralateral untrained limb (\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.68;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.001), while mid\u2010thigh muscle mass (\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u20090.24;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.013) and whole\u2010body physical function assessed through the timed up\u2010and\u2010go test improved only after light\u2010load PT (\n                    <jats:italic>d<\/jats:italic>\n                    \u2009=\u2009\u22120.74;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In conclusion, unilateral PT induced significant contralateral gains in dynamic muscle strength and power, regardless of training intensity, with heavier loads enhancing velocity\u2010specific adaptations. Notably, light\u2010load PT induced mild hypertrophy in the contralateral untrained limb and whole\u2010body physical function, which might be particularly relevant for enhancing the intrinsic capacity of older adults.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    ID: NCT03724461\n                  <\/jats:p>","DOI":"10.1111\/sms.70165","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:53:47Z","timestamp":1762955627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Contralateral Adaptations After Unilateral Power Training in Older Adults: The Effect of Intensity of Load"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-7476","authenticated-orcid":false,"given":"Carlos","family":"Rodriguez\u2010Lopez","sequence":"first","affiliation":[{"name":"Department of Geriatrics Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Health Research Institute Gregorio Mara\u00f1\u00f3n  Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES) Instituto de Salud Carlos III  Madrid Spain"},{"name":"GENUD Toledo Research Group, Faculty of Sport Sciences University of Castilla\u2010La Mancha  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1090-5482","authenticated-orcid":false,"given":"Julian","family":"Alcazar","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable (CIBERFES) Instituto de Salud Carlos III  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