{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:38:25Z","timestamp":1790887105839,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Patellar tendinopathy (PT) is a debilitating overuse injury, and one of the current recommended treatments is heavy slow resistance training (HSRT); Recently, low\u2010load resistance training combined with blood flow restriction (LL\u2010BFRT) has been advocated as a clinically relevant rehabilitation tool for PT since it does not involve large joint and tissue stresses and may accelerate recovery. This study aimed to investigate the effect of LL\u2010BFRT compared with HSRT at 3, 6, 12 (primary endpoint), and 52\u2009weeks. Participants with chronic unilateral PT were randomized to a 12\u2010week rehabilitation program based on either LL\u2010BFRT (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916) or HSRT (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920). The primary outcome was pain (numerical rating scale (NRS) 0\u201310) during a single\u2010leg decline squat (SLDS). Secondary outcome variables included the Victorian Institute of Sports Assessment\u2010Patella questionnaire (VISA\u2010P), maximal isometric knee extensor strength, patellar tendon morphology assessed by ultrasonography (swelling, vascularization), and magnetic resonance imaging (MRI). Comparable clinically relevant improvements in pain (NRS during SLDS, least squares mean\u2009\u00b1\u2009SEM) were observed in LL\u2010BFRT (LL\u2010BFRT: 0\u2009weeks 3.9\u2009\u00b1\u20090.5, 12\u2009weeks 2.2\u2009\u00b1\u20090.5, 52\u2009weeks 1.8\u2009\u00b1\u20090.5) and HSRT (0\u2009weeks 4.2\u2009\u00b1\u20090.4, 12\u2009weeks 2.2\u2009\u00b1\u20090.4, 52\u2009weeks 1.1\u2009\u00b1\u20090.5) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Likewise, clinically relevant improvements were reported on the VISA\u2010P score. LL\u2010BFRT and HSRT resulted in comparable short\u2010term and long\u2010term clinical improvements in males with chronic PT. These data advocate that LL\u2010BFRT represents an effective rehabilitation tool in the treatment of chronic PT, while preventing high joint and tendon loads.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.org\">Clinicaltrials.org<\/jats:ext-link>\n                    (NCT04550013)\n                  <\/jats:p>","DOI":"10.1111\/sms.70186","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T15:23:30Z","timestamp":1766762610000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Low\u2010Load Blood\u2010Flow Restricted Training Versus Heavy Slow Resistance Training in Unilateral Patellar Tendinopathy: A Randomized Clinical Trial"],"prefix":"10.1111","volume":"35","author":[{"given":"Mikkel Holm","family":"Hjortshoej","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Institute of Sports Medicine Copenhagen Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Physical and Occupational Therapy Bispebjerg and Frederiksberg University Hospital  Copenhagen Denmark"},{"name":"Centre for Health and Rehabilitation University College Absalon  Slagelse Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant","family":"Juneja","sequence":"additional","affiliation":[{"name":"Centre for Health and Rehabilitation University College Absalon  Slagelse Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 Br\u00fcggebusch","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Institute of Sports Medicine Copenhagen Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Health Technology, Center for Fast Ultrasound Imaging Technical University of Denmark  Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Bennike","family":"Herzog","sequence":"additional","affiliation":[{"name":"Department of Physical and Occupational Therapy Bispebjerg and Frederiksberg University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Lundgaard\u2010Nielsen","sequence":"additional","affiliation":[{"name":"Department of Physical and Occupational Therapy Bispebjerg and Frederiksberg University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik Kronvold","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Physical and Occupational Therapy Bispebjerg and Frederiksberg University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette With","family":"Wulff","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Institute of Sports Medicine Copenhagen Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Emilie","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Institute of Sports Medicine Copenhagen Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Institute of Sports Medicine Copenhagen Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Aagaard","sequence":"additional","affiliation":[{"name":"Department of Sports Science and Clinical Biomechanics University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4308-5484","authenticated-orcid":false,"given":"Stig Peter","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Institute of Sports Medicine Copenhagen Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen 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