{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:31:48Z","timestamp":1790404308955,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Inflammatory processes may contribute to running\u2010related injury (RRI) susceptibility, yet the predictive value of baseline inflammatory biomarkers remains unclear. This prospective study investigated whether baseline biochemical markers of inflammation predict RRI occurrence in healthy individuals over 1\u2009year, while accounting for training, physiological, and injury history variables. A total of 1315 healthy individuals (recreational runners and inactive controls) were followed for 12\u2009months with prospective injury surveillance. Baseline blood samples were analyzed for inflammatory markers. Multivariable logistic regression examined associations between baseline biomarkers and RRI occurrence, adjusting for age, sex, peak oxygen consumption, weekly running distance, total body fat, and history of musculoskeletal trauma. Significant predictors of RRI included baseline tumor necrosis factor alpha (TNF\u2010\u03b1) (OR per 1\u2009pg\/mL: 1.25, 95% CI: 1.08\u20131.44), history of musculoskeletal trauma (OR: 1.42, 95% CI: 1.06\u20131.90), weekly running distance, and age. Interleukin\u20101 receptor antagonist (IL\u20101RA) showed a modest protective association (OR per 10\u2009pg\/mL: 0.99, 95% CI: 0.99\u20131.00). However, the model demonstrated limited discriminatory ability (AUC\u2009=\u20090.66), indicating that baseline inflammatory markers alone are insufficient for individual\u2010level injury prediction. Baseline TNF\u2010\u03b1 and IL\u2010RA are significantly associated with RRI occurrence, suggesting that inflammatory phenotype contributes to injury susceptibility. However, TNF\u2010\u03b1 and IL\u20101RA cannot serve as reliable standalone screening tools, and our findings indicate that baseline inflammatory phenotype represents one component of multifactorial injury risk. While baseline TNF\u2010\u03b1 and IL\u20101RA measurements are unlikely to transform clinical practice in isolation, understanding inflammatory contributions to injury susceptibility may inform more effective injury\u2010prevention strategies.<\/jats:p>","DOI":"10.1111\/sms.70225","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:25:38Z","timestamp":1770884738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Baseline Inflammatory Markers as Predictors of Running\u2010Related Injuries: A One\u2010Year Prospective\n                    <scp>4HAIE<\/scp>\n                    Cohort Study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2403-8797","authenticated-orcid":false,"given":"Lukas","family":"Cipryan","sequence":"first","affiliation":[{"name":"Department of Human Movement Studies &amp; Human Motion Diagnostic Centre The University of Ostrava  Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3617-2926","authenticated-orcid":false,"given":"Jiri","family":"Skypala","sequence":"additional","affiliation":[{"name":"Department of Human Movement Studies &amp; Human Motion Diagnostic Centre The University of Ostrava  Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Litschmannova","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics, Faculty of Electrical Engineering and Computer Science VSB \u2013 Technical University of Ostrava  Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2653-2569","authenticated-orcid":false,"given":"Daniel","family":"Jandacka","sequence":"additional","affiliation":[{"name":"Department of Human Movement Studies &amp; Human Motion Diagnostic Centre The University of Ostrava  Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Dostal","sequence":"additional","affiliation":[{"name":"Department of Human Movement Studies &amp; Human Motion Diagnostic Centre The University of Ostrava  Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Sindler","sequence":"additional","affiliation":[{"name":"Department of Human Movement Studies &amp; Human Motion Diagnostic Centre The University of Ostrava  Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zahradnik","sequence":"additional","affiliation":[{"name":"Department of Human Movement Studies &amp; Human Motion Diagnostic Centre The University of Ostrava  Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Department of Human Movement Studies &amp; Human Motion Diagnostic Centre The University of Ostrava  Ostrava Czech Republic"},{"name":"Institute of Human Movement Science, Sport &amp; Health University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2018-100493"},{"key":"e_1_2_13_3_1","article-title":"Health Benefits of Different Sports: A Systematic Review and Meta\u2010Analysis of Longitudinal and Intervention Studies Including 2.6 Million Adult Participants","volume":"10","author":"Oja P.","year":"2024","journal-title":"Sports Medicine"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13772"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2007.044677"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2024-109380"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2021.04.001"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13102-022-00397-2"},{"key":"e_1_2_13_9_1","article-title":"Low\u2010Grade Chronic Inflammation: A Shared Mechanism for Chronic Diseases","volume":"40","author":"Cifuentes M.","year":"2025","journal-title":"Physiology (Bethesda)"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1434533"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.006"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00019.2013"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11152397"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-018-0328-y"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-44270-4_9"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2024.04.011"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000003617"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-040529"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17239142"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-10166-4"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12883"},{"key":"e_1_2_13_22_1","volume-title":"Guidelines for Exercise Testing and Prescription (ACSM)","author":"Riebe D.","year":"2018"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247057"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1178913"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ptsp.2019.06.003"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.2015.5741"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-032627"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40279-014-0194-6"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.156006"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.280.4.C769"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.04.001"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1133355"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71071-2"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9661823"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199808)28:08<2598::AID-IMMU2598>3.0.CO;2-K"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107423"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuaf104"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods11162524"}],"container-title":["Scandinavian Journal of Medicine &amp; 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