{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:13:35Z","timestamp":1788498815997,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Current exercise guidelines emphasize a total weekly volume of exercise (i.e., 150\u2009min\/week), but the optimal weekly frequency remains uncertain. Therefore, this randomized clinical trial aimed to compare the effects of combined resistance and aerobic training either two or four times per week, at the same total weekly volume, on office and ambulatory blood pressure in older adults with hypertension. Participants were randomized to exercise training performed either twice per week (CT2,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200949) or four times per week (CT4,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200949), for 12\u2009weeks. Primary outcome was 24\u2010h ambulatory BP; secondary outcomes included office BP and physical fitness, assessed at baseline and post\u2010intervention. Of the 98 randomized participants (66% women; mean age 64\u2009\u00b1\u20097\u2009years), all were included in the intention\u2010to\u2010treat analysis, whereas 63 were retained for the per\u2010protocol analysis after excluding those with low adherence (&lt;\u200980%) or missing post\u2010intervention data. Although no significant differences between groups were observed in office and ambulatory BP in the intention\u2010to\u2010treat analysis, office systolic (\u22128\u2009mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) and diastolic BP (\u22123\u2009mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) reduced in CT4 (\u22128\u2009mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), and systolic BP decreased in CT2 after training (\u22124\u2009mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.032). In the per\u2010protocol analysis, office systolic BP was lower in CT4 than CT2 after training (\u22126\u2009mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.049). CT4 demonstrated significant reductions in 24\u2010h systolic (\u22124\u2009mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012) and diastolic BP (\u22122\u2009mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.010) after training. Cardiorespiratory fitness improved in CT4 (\u0394\u2009=\u20098%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) but not in CT2. Our findings suggest that higher weekly frequency may optimize blood pressure management in hypertension, although these additional benefits appear to be dependent on high protocol adherence.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/\">ClinicalTrials.gov<\/jats:ext-link>\n                    Identifier: NCT04218903\n                  <\/jats:p>","DOI":"10.1111\/sms.70239","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:19:47Z","timestamp":1772983187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differential Effects of Twice vs. Four Times Weekly Combined Exercise Training in Aging Adults With Hypertension: A Randomized Clinical 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De Porto Alegre  RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Betti","family":"Domingues","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Cardiology, School of Medicine Universidade Federal Do Rio Grande Do Sul  Porto Alegre RS Brazil"},{"name":"Sports and Exercise Training Study Group, Clinical Research Center Hospital De Cl\u00ednicas De Porto Alegre  RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Abreu","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Cardiology, School of Medicine Universidade Federal Do Rio Grande Do Sul  Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Lemes","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Cardiology, School of Medicine Universidade Federal Do Rio Grande Do Sul  Porto Alegre RS Brazil"},{"name":"Postgraduate Program in Human Movement 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