{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T12:51:52Z","timestamp":1785761512817,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This secondary integrative analysis of a previously published cohort investigated the molecular pathways underlying muscle recovery of the biceps femoris long head (BF\n                    <jats:sub>LH<\/jats:sub>\n                    ) after a football match, by integrating newly generated transcriptomic data with clinical recovery markers over a 72\u2010h recovery period. BF\n                    <jats:sub>LH<\/jats:sub>\n                    muscle biopsies from 10 male, regional\u2010first division football players were obtained 7\u2009days before a football match (MD\n                    <jats:sub>\u22127<\/jats:sub>\n                    ) and 3\u2009days post\u2010match (MD\n                    <jats:sub>+3<\/jats:sub>\n                    ). The final sample included 9 participants because 1 biopsy provided insufficient material for sequencing. Bulk RNA\u2010sequencing was conducted to analyze differential gene expression considering Benjamini\u2010Hochberg correction. Pathway enrichment analyses were conducted to identify biological processes altered between pre\u2010 and post\u2010match conditions. Clinical markers, including creatine kinase (CK), hamstring rate of torque development (RTD), and sprint performance, were assessed before the match (MD) and at 24 (MD\n                    <jats:sub>+1<\/jats:sub>\n                    ), 48 (MD\n                    <jats:sub>+2<\/jats:sub>\n                    ), and 72\u2009h (MD\n                    <jats:sub>+3<\/jats:sub>\n                    ) post\u2010match. Correlations between transcriptomic and clinical variables were calculated using Spearman's rank correlation.\n                    <jats:italic>MYH1<\/jats:italic>\n                    was the most responsive gene, showing significant downregulation at MD\n                    <jats:sub>+3<\/jats:sub>\n                    (log\n                    <jats:sub>2<\/jats:sub>\n                    FC\u2009=\u2009\u22121.116,\n                    <jats:italic>q<\/jats:italic>\n                    \u2010value\u2009=\u20093.8\u2009\u00d7\u200910\n                    <jats:sup>\u22122<\/jats:sup>\n                    ). Pathway analyses identified 440 transcriptomic signatures at MD\n                    <jats:sub>+3<\/jats:sub>\n                    , reflecting stress response, immune and cytokine signaling, protein turnover, and structural remodeling. Changes in clinical variables during recovery were associated with coordinated expression shifts across genes related to different phases of the muscle damage\u2010regeneration continuum, including muscle contraction, damage control, protein turnover, repair signaling, and myogenic regeneration. BF\n                    <jats:sub>LH<\/jats:sub>\n                    is not fully recovered 3\u2009days after a football match, as evidenced by sustained downregulation of\n                    <jats:italic>MYH1<\/jats:italic>\n                    , pathway enrichment, and associations with clinical markers. Molecular recovery processes extend beyond 72\u2009h, suggesting this period is insufficient for complete BF\n                    <jats:sub>LH<\/jats:sub>\n                    recovery in football players.\n                  <\/jats:p>","DOI":"10.1111\/sms.70339","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:44:37Z","timestamp":1784123077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptomic Profiling of the Biceps Femoris Long Head 72\u2009h Following a Football Match and Associations With Recovery Biomarkers"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1728-2046","authenticated-orcid":false,"given":"Pedro L.","family":"Cosio","sequence":"first","affiliation":[{"name":"Institut Nacional d'Educaci\u00f3 F\u00edsica de Catalunya (INEFC), Universitat de Barcelona (UB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6338-9218","authenticated-orcid":false,"given":"Iago","family":"Pinal\u2010Fernandez","sequence":"additional","affiliation":[{"name":"Muscle Disease Section National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health  Bethesda Maryland USA"},{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9516-1696","authenticated-orcid":false,"given":"Lia","family":"Moreno\u2010Simonet","sequence":"additional","affiliation":[{"name":"Institut Nacional d'Educaci\u00f3 F\u00edsica de Catalunya (INEFC), Universitat de Barcelona (UB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6020-189X","authenticated-orcid":false,"given":"Joan A.","family":"Cadefau","sequence":"additional","affiliation":[{"name":"Institut Nacional d'Educaci\u00f3 F\u00edsica de Catalunya (INEFC), Universitat de Barcelona (UB)  Barcelona Spain"},{"name":"Faculty of Medicine and Health Sciences Universitat de Barcelona (UB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3732-3252","authenticated-orcid":false,"given":"Andrew L.","family":"Mammen","sequence":"additional","affiliation":[{"name":"Muscle Disease Section National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health  Bethesda Maryland USA"},{"name":"Department of Neurology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8060-3914","authenticated-orcid":false,"given":"Gil","family":"Rodas","sequence":"additional","affiliation":[{"name":"Sports Medicine Unit Hospital 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