{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:38:47Z","timestamp":1787593127493,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Regular endurance exercise is widely recognized for its cardiovascular health benefits, with improvements in vascular function particularly relevant for populations with impaired vascular health. However, it is unknown whether prolonged adherence to endurance exercise training in sedentary but healthy young individuals can improve vascular function in non\u2010active limbs. This study investigated the impact of 1\u2009year of supervised endurance exercise on vascular function in previously untrained, healthy young participants. Twelve healthy young adults (25\u2009\u00b1\u20094\u2009years) were included in a 12\u2010month supervised cycling program, during which maximal aerobic capacity (V\u0307O\n                    <jats:sub>2<\/jats:sub>\n                    max) and vascular function were assessed at baseline and after 1, 4, 6, and 12\u2009months of training. Forearm vascular function was assessed using intra\u2010arterial infusions of acetylcholine (ACh; endothelium\u2010dependent vasodilation) and sodium nitroprusside (SNP; endothelium\u2010independent vasodilation) and flow\u2010mediated dilation (FMD). Seven participants completed the 12\u2010month protocol and showed no change in endothelium\u2010dependent or independent vasodilation assessment at any time point during the 12\u2010month training period (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05), despite a substantial increase in aerobic capacity during the first 6\u2009months of training (baseline: 40.3 vs. 6\u2009months: 50.8\u2009mL\u00b7min\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), with no further change observed from 6 to 12\u2009months (51.3\u2009mL\u00b7min\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). One year of endurance exercise training improved aerobic capacity without improving vascular function in non\u2010trained limbs in previously untrained but healthy individuals. These findings support the idea that vascular adaptations to endurance training may reflect a region\u2010specific training effect with vascular remodeling confined to actively engaged limbs and, thus, undetectable in vascular territories not directly involved in exercise training.\n                  <\/jats:p>","DOI":"10.1111\/sms.70354","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:28:32Z","timestamp":1787304512000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One Year of Endurance Exercise Training Does not Improve Vascular Function in Non\u2010Trained Limbs in Healthy Individuals"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0390-3139","authenticated-orcid":false,"given":"Marcos Paulo","family":"Rocha","sequence":"first","affiliation":[{"name":"The August Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6929-0072","authenticated-orcid":false,"given":"Casper","family":"Sejersen","sequence":"additional","affiliation":[{"name":"The August Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6403-1100","authenticated-orcid":false,"given":"Mads","family":"Fischer","sequence":"additional","affiliation":[{"name":"The August Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1554-6802","authenticated-orcid":false,"given":"Andrea","family":"Tamariz\u2010Ellemann","sequence":"additional","affiliation":[{"name":"The August Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4714-1981","authenticated-orcid":false,"given":"Thomas","family":"Bonne","sequence":"additional","affiliation":[{"name":"The August Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9698-9188","authenticated-orcid":false,"given":"Jacob","family":"Bejder","sequence":"additional","affiliation":[{"name":"The August Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1684-0026","authenticated-orcid":false,"given":"Carsten","family":"Lundby","sequence":"additional","affiliation":[{"name":"The August Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7077-9265","authenticated-orcid":false,"given":"Nikolai B.","family":"Nordsborg","sequence":"additional","affiliation":[{"name":"The August Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports University of Copenhagen  Copenhagen 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