{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:01:40Z","timestamp":1790136100427,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2020QH1143"],"award-info":[{"award-number":["2020QH1143"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2026J001154"],"award-info":[{"award-number":["2026J001154"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2023Y9276"],"award-info":[{"award-number":["2023Y9276"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2023R0123"],"award-info":[{"award-number":["2023R0123"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2023L3018"],"award-info":[{"award-number":["2023L3018"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Right heart geometry and function are essential for preserving physical performance in healthy aging, yet evidence regarding how long\u2010term supervised multicomponent exercise influences right heart characteristics and cardiopulmonary reserve over time remains limited. To address this gap, this interim analysis of a prospective, non\u2010randomized, two\u2010armed cohort study included 155 adults aged \u2265\u200965\u2009years assigned to supervised multicomponent training (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200975) or education control group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200980). Cardiac magnetic resonance imaging and cardiopulmonary exercise testing were performed at baseline, 1\u2010year, and 2\u2010year follow\u2010ups, with right heart structure and function as the primary outcomes; post hoc analyses were stratified by training adherence. Among these participants, 92 (training:\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200954; control:\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200938) completed the 2\u2010year follow\u2010up and were included in the final analysis. No significant time \u00d7 group interactions were detected for right or left heart parameters (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). After multivariable adjustment, the exercise group showed higher overall adjusted mean values for right atrial volumes and selected right ventricular functional measures, including stroke volume, cardiac index, and peak filling rate (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In contrast, significant time \u00d7 group interactions were identified for peak VO\n                    <jats:sub>2<\/jats:sub>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003), and VO\n                    <jats:sub>2<\/jats:sub>\n                    at AT (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.033), indicating distinct longitudinal cardiopulmonary trajectories between groups. Post hoc subgroup analyses showed that between\u2010group differences in right heart volumetric measures persisted through 2\u2009years in the high\u2010adherence group, whereas those in the low\u2010adherence group were less consistent. Overall, long\u2010term multicomponent exercise was associated with higher levels of selected right heart volumetric and functional measures without detectable alterations in longitudinal cardiac remodeling trajectories in older adults, alongside favorable longitudinal changes in cardiopulmonary reserve. These findings suggest that exercise\u2010related benefits in healthy aging may be characterized primarily by functional adaptations rather than longitudinal structural cardiac remodeling.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    The original study was registered at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.chictr.org.cn\/bin\/userProject\">https:\/\/www.chictr.org.cn\/bin\/userProject<\/jats:ext-link>\n                    (ChiCTR2000032404, Registered on April 27, 2020)\n                  <\/jats:p>","DOI":"10.1111\/sms.70368","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:40:08Z","timestamp":1789022408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Right Heart Cardiac Magnetic Resonance Profiles and Cardiopulmonary Reserve in Older Adults Undergoing Long\u2010Term Multicomponent Exercise: A 2\u2010Year Longitudinal Study"],"prefix":"10.1111","volume":"36","author":[{"given":"Tingting","family":"Liu","sequence":"first","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Song","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Ye","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University  Fuzhou China"},{"name":"Fuzhou University Affiliated Provincial Hospital  Fuzhou China"},{"name":"Fujian Provincial Institute of Clinical Geriatrics  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7857-3971","authenticated-orcid":false,"given":"Cai","family":"Jiang","sequence":"additional","affiliation":[{"name":"Fuzhou University Affiliated Provincial Hospital  Fuzhou China"},{"name":"Fujian Key Laboratory of Geriatrics  Fuzhou China"},{"name":"Fujian Provincial Center for Geriatrics  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalan","family":"Dai","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical 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Provincial Institute of Clinical Geriatrics  Fuzhou China"},{"name":"Fujian Key Laboratory of Geriatrics  Fuzhou China"},{"name":"Fujian Provincial Center for Geriatrics  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"Fuzhou University Affiliated Provincial Hospital  Fuzhou China"},{"name":"Fujian Provincial Center for Geriatrics  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_15_2_1","first-page":"1","article-title":"A Biomarker Framework for Cardiac Aging: The Aging Biomarker Consortium Consensus Statement","volume":"2","author":"Zhang W.","year":"2023","journal-title":"Lifestyle 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