{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:59:50Z","timestamp":1790135990048,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100008752","name":"Deutsche Sporthochschule K\u00f6ln","doi-asserted-by":"publisher","award":["L\u201011\u201010011\u2010283\u2010093000"],"award-info":[{"award-number":["L\u201011\u201010011\u2010283\u2010093000"]}],"id":[{"id":"10.13039\/501100008752","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cycling is recommended as a conservative treatment for managing knee osteoarthritis (KOA), yet direct comparisons of knee joint loading between cycling and weight\u2010bearing locomotion are limited. This study compared fatigue\u2010weighted cumulative knee joint loading (\n                    <jats:italic>wCKL<\/jats:italic>\n                    ) across cycling, walking, and running in individuals with and without KOA. Fifty\u2010six recreational cyclists (19 KOA, 19 age\u2010matched controls, 18 young controls) performed cycling at nine cadence\u2010power combinations (60\/80\/100\u2009rpm\u2009\u00d7\u2009157\/210\/261\u2009W), walking at 1.4\u2009m\/s, and running at 3.0\u2009m\/s. Three\u2010dimensional kinematics and reaction forces (ground for walking\/running, pedal for cycling) were used to compute external knee moments via OpenSim.\n                    <jats:italic>wCKL<\/jats:italic>\n                    was calculated from sagittal\u2010plane and frontal\u2010plane knee moments and scaled to 1\u2009h of activity. Mixed\u2010effects linear models tested task\u2010 and group\u2010dependent effects, and dose\u2010equivalence estimates were derived to relate cycling duration to equivalent walking or running exposure. Across planes, cycling produced lower\n                    <jats:italic>wCKL<\/jats:italic>\n                    than running and was not greater than walking. In the sagittal plane, cycling and walking showed comparable\n                    <jats:italic>wCKL<\/jats:italic>\n                    across groups, whereas KOA exhibited reduced sagittal\n                    <jats:italic>wCKL<\/jats:italic>\n                    relative to controls during running. In the frontal plane, KOA demonstrated significantly elevated\n                    <jats:italic>wCKL<\/jats:italic>\n                    during walking and running but not cycling. Dose\u2010equivalence analyses indicated that cycling would need to be performed ~1\u20132\u2009h to match 1\u2009h of walking and ~3\u20135\u2009h to match 1\u2009h of running, with larger ratios in the frontal plane for KOA. These findings demonstrate that cycling limits cumulative knee loading compared with running without exceeding walking under the tested conditions.\n                  <\/jats:p>","DOI":"10.1111\/sms.70369","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:13:19Z","timestamp":1789557199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparing Knee Joint Load Accumulation During Cycling, Walking, and Running in Individuals With and Without Knee Osteoarthritis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2991-2698","authenticated-orcid":false,"given":"Jonas","family":"Ebbecke","sequence":"first","affiliation":[{"name":"Institute of Biomechanics and Orthopaedics German Sport University Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0401-885X","authenticated-orcid":false,"given":"Lasse","family":"Hansen","sequence":"additional","affiliation":[{"name":"Institute of Biomechanics and Orthopaedics German Sport University Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5106-9513","authenticated-orcid":false,"given":"Josef","family":"Viellehner","sequence":"additional","affiliation":[{"name":"Institute of Biomechanics and Orthopaedics German Sport University Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3623-9764","authenticated-orcid":false,"given":"William Brent","family":"Edwards","sequence":"additional","affiliation":[{"name":"Human Performance Laboratory, Faculty of Kinesiology University of Calgary  Calgary Canada"},{"name":"McCaig Institute for Bone and Joint Health University of Calgary  Calgary Canada"},{"name":"Department of Biomedical Engineering University of Calgary  Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8927-4053","authenticated-orcid":false,"given":"Nina","family":"Naeckel","sequence":"additional","affiliation":[{"name":"Institute of Biomechanics and Orthopaedics German Sport University Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9135-3802","authenticated-orcid":false,"given":"Wolfgang","family":"Potthast","sequence":"additional","affiliation":[{"name":"Institute of Biomechanics and Orthopaedics German Sport University Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42089"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34453"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:ABME.0000017541.82498.37"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.7.617"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.09.012"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201030058\u20104"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.603907"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000759"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/23259671231172773"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2017.03.007"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.07.005"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/54.4.M184"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215520971795"},{"key":"e_1_2_11_15_1","first-page":"22","article-title":"Exercise\u2010Induced Effects on Inflammatory Markers and Brain\u2010Derived Neurotrophic Factor in Patients With Knee Osteoarthritis. 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