{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:11:43Z","timestamp":1761394303191},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T00:00:00Z","timestamp":1363910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Nail lesions are common features of psoriasis and found in almost half of the patients. However, there is no feasible spectroscopic method evaluating changes and severity of nail psoriasis. <jats:styled-content style=\"fixed-case\">EPR<\/jats:styled-content> (electron paramagnetic resonance) might be feasible for evaluating nail conditions in the patients of psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Finger nails of five cases with nail psoriasis, (three females and two males) were examined. Nail samples were subjected to the EPR assay. The small piece of the finger nail (1.5\u00a0\u00d7\u00a05\u00a0mm<jats:sup>2<\/jats:sup>) was incubated in ~50\u00a0\u03bcM 5\u2010DSA (5\u2010doxylstearic acid) aqueous solutions for about 60\u00a0min at 37\u00b0C. After rinsing and wiping off the excess 5\u2010DSA solution, the nail samples were measured by EPR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">EPR<\/jats:styled-content> spectra were analyzed using the intensity ratio (<jats:italic>Fast\/Slow<\/jats:italic>) of the two motions at the peaks of the lower magnetic field. We observed two distinguishable sites on the basis of the <jats:styled-content style=\"fixed-case\">EPR<\/jats:styled-content> results. In addition, the modern <jats:styled-content style=\"fixed-case\">EPR<\/jats:styled-content> calculation was performed to analyze the spectra obtained. The nail psoriasis\u2010related region is 2~3 times higher than that of the control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present <jats:styled-content style=\"fixed-case\">EPR<\/jats:styled-content> results show that there are two distinguishable sites in the nail. In the case of nail psoriasis, the fragile components are 2~3 times more than those of the control. Thus, the <jats:styled-content style=\"fixed-case\">EPR<\/jats:styled-content> method is thought to be a novel and reliable method of evaluating the nail psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12068","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T08:48:02Z","timestamp":1364028482000},"page":"450-453","source":"Crossref","is-referenced-by-count":3,"title":["<scp>EPR<\/scp> spectroscopic investigation of psoriatic finger nails"],"prefix":"10.1111","volume":"19","author":[{"given":"Kouichi","family":"Nakagawa","sequence":"first","affiliation":[{"name":"Department of Radiological Life Sciences Graduate School of Health Sciences Hirosaki University 66\u20101 Hon\u2010cyo Hirosaki 036\u20108564 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Minakawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medicine Hirosaki University 5 Zaifu\u2010cyo Hirosaki 036\u20108562 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Sawamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medicine Hirosaki University 5 Zaifu\u2010cyo Hirosaki 036\u20108562 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2012.01.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2010.00491.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-009-3374-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1201\/b15273-20"},{"key":"e_1_2_6_6_1","unstructured":"EasySpin 4.0.0 version(an internet available academic program) was used to calculate the fast and slow motional EPR spectra. http:http:\/\/www.easyspin.org\/"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(90)90039-Y"},{"key":"e_1_2_6_8_1","first-page":"310","volume-title":"Theory of magnetic resonance","author":"Poole CP","year":"1987"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12068","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T23:17:29Z","timestamp":1696202249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,22]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/srt.12068"],"URL":"https:\/\/doi.org\/10.1111\/srt.12068","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,22]]}}}