{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:07:53Z","timestamp":1785186473938,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,5,25]],"date-time":"2013-05-25T00:00:00Z","timestamp":1369440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Background<\/jats:title>Facial erythema is a common but morbid condition caused by several inflammatory disorders. Since most of the current severity indexes lack objectivity and global assessment, the computer\u2010aided image analysis (CAIA<\/jats:styled-content>) has been suggested.<\/jats:p><\/jats:sec>Objective<\/jats:title>The purpose of this study is to compare the validity and efficacy of novel CAIA<\/jats:styled-content> erythema index \u2013 erythema dose (ED<\/jats:styled-content>) with two other CAIA<\/jats:styled-content> indexes.<\/jats:p><\/jats:sec>Methods<\/jats:title>For mild, moderated and severe erytherotelangiectatic rosacea patients, their photographs of right cheek were assessed with red\u2010blue difference index in image (RBI<\/jats:styled-content>), a<\/jats:italic>*, and ED<\/jats:styled-content>. For each index, the differences between severity groups were analyzed. The correlations between the three indexes were evaluated. To evaluate the capability of differentiating the pathologic erythema from the red component of the normal skin, each index was calculated at both the erythema and normal area.<\/jats:p><\/jats:sec>Results<\/jats:title>The a<\/jats:italic>* and ED<\/jats:styled-content> significantly changed according to the severity, while the RBI<\/jats:styled-content> did not. The ED<\/jats:styled-content> was different between both mild\u2010moderate and moderate\u2010severe, while the a<\/jats:italic>* only between mild\u2010moderate. There was a strong positive correlation between a<\/jats:italic>* and ED<\/jats:styled-content>. The difference between erythema and normal skin was more prominent in ED<\/jats:styled-content> than in a<\/jats:italic>*.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We confirmed that the ED<\/jats:styled-content> is well correlated with both subjective assessment, as well as the other CAIA<\/jats:styled-content> index a<\/jats:italic>*. The ED<\/jats:styled-content> has the advantage of specifically visualizing and analyzing the pathologic erythema.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12075","type":"journal-article","created":{"date-parts":[[2013,5,25]],"date-time":"2013-05-25T06:09:14Z","timestamp":1369462154000},"page":"8-13","source":"Crossref","is-referenced-by-count":9,"title":["Erythema dose \u2010 a novel global objective index for facial erythema by computer\u2010aided image analysis"],"prefix":"10.1111","volume":"20","author":[{"given":"Jae Woo","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University, College of Medicine and Seoul National University, Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Hyo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University, College of Medicine and Seoul National University, Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Moon","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University, College of Medicine and Seoul National University, Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Woong","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University, College of Medicine and Seoul National University, Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,25]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"16","article-title":"Advances in understanding and managing rosacea: part 1: connecting the dots between pathophysiological mechanisms and common clinical features of rosacea with emphasis on vascular changes and facial erythema","volume":"5","author":"Rosso 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