{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:34:03Z","timestamp":1791293643244,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T00:00:00Z","timestamp":1371600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The monitoring of wound\u2010healing processes is indispensable for the therapeutic effectiveness and improved care of chronic wounds. Histological sections provide the best morphological assessment of wound recovery, but cause further tissue destruction and increase the risk of infection. Therefore, it is reasonable to apply a diagnostic tool that allows a non\u2010invasive and reliable observation of morphological changes in wound healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Optical coherence tomography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) is an imaging technique for <jats:italic>in vivo<\/jats:italic> evaluation of skin diseases with a resolution close to histopathology. The aim of this study was to investigate whether <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> is suited to display the phases of wound healing. For this purpose, six patients with chronic wounds were objectively characterized by <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> during a period of 2\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparable results between histological findings and <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> were achieved. <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> allowed the detection of partial loss of the epidermis, vasoconstriction, vasodilatation and epithelialization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Consequently, <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> could be a potential non\u2010invasive diagnostic tool for the characterization and monitoring of cutaneous wound\u2010healing processes over 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