{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T18:57:52Z","timestamp":1772045872461,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Vascular abnormalities play an acute role in the pathogenesis of psoriasis. In order to characterize vascular involvement in psoriasis and its regular clinical assessment<jats:italic>in vivo<\/jats:italic>, non\u2010invasive high speed imaging with high resolution and high sensitivity is needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The correlation mapping optical coherence tomography (cm<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) technique was used for<jats:italic>in vivo<\/jats:italic>microcirculation imaging of human forearm under normal and psoriatic conditions. The cm<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>technique developed by our group uses dense scanning<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>image acquisition and post\u2010processing software based on correlation statistics. The frequency domain<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>system was used for imaging which acquires a 3D volume of 1024\u00a0\u00d7\u00a01024 A\u2010scans, each of 512 pixels deep in approximately 70\u00a0s. The cm<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>technique processes the resulting<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>volume within 116 s using a 7\u00a0\u00d7\u00a07 kernel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>3D structural and functional (microcirculation) maps of the healthy tissue and the psoriatic plaque were obtained using the cm<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>technique. The presented results indicate that cm<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>allows not only the identification of the microvessels, but also produces more detailed microvascular networks showing how the blood vessels relate to each other in healthy tissue and within the plaque. The microcirculation pattern within the plaque is totally different from the healthy tissue. The distinct changes are also observed in vessel density, tortuosity, and orientation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The cm<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>provides high sensitivity and imaging speed for<jats:italic>in vivo<\/jats:italic>microcirculation imaging within the human skin under normal and diseased conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12096","type":"journal-article","created":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T05:46:55Z","timestamp":1374472015000},"page":"141-146","source":"Crossref","is-referenced-by-count":13,"title":["Assessment of psoriatic plaque<i>in vivo<\/i>with correlation mapping optical coherence tomography"],"prefix":"10.1111","volume":"20","author":[{"given":"H.","family":"Zafar","sequence":"first","affiliation":[{"name":"School of Physics Tissue Optics and Microcirculation Imaging Group National University of Ireland Galway Ireland"},{"name":"National Biophotonics and Imaging Platform Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Enfield","sequence":"additional","affiliation":[{"name":"National Biophotonics and Imaging Platform Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. \u2010L.","family":"O'Connell","sequence":"additional","affiliation":[{"name":"National Biophotonics and Imaging Platform Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Ramsay","sequence":"additional","affiliation":[{"name":"Dermatology Unit Mid\u2010Western Regional Hospital Dooradoyle Limerick Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Dermatology Unit Mid\u2010Western Regional Hospital Dooradoyle Limerick Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Leahy","sequence":"additional","affiliation":[{"name":"School of Physics Tissue Optics and Microcirculation Imaging Group National University of Ireland Galway Ireland"},{"name":"National Biophotonics and Imaging Platform Dublin Ireland"},{"name":"Royal College of Surgeons Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/17469872.1.1.63"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1976.tb01424.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2005.00303.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000057888"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.2009.00913.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900130205"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20085"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/49\/7\/020"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20612"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.35.001521"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1220"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2002.800510.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20977"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.15.004083"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/jbio.201000103","article-title":"Correlation mapping method for generating microcirculation morphology from OCT intensity images","volume":"4","author":"Jonathan E","year":"2011","journal-title":"J Biophotonics"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.2.001184"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90357-U"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12096","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T04:24:59Z","timestamp":1715747099000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,22]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/srt.12096"],"URL":"https:\/\/doi.org\/10.1111\/srt.12096","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,22]]}}}