{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:17:03Z","timestamp":1792073823823,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We usually divided cosmetic facial zone into the T zone and U zone by the level of sebum secretion. Our recent studies suggested that the perioral area showed different characteristics in the aspect of acne development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the unique characteristics of the O zone (perioral area) among the three facial areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 102 patients clinically diagnosed as acne vulgaris were included. The acne lesions were counted from the clinical digital photographs by facial areas. The sebum level was measured using Sebumeter<jats:sup>\u00ae<\/jats:sup>. Area\u2010weighted (<jats:styled-content style=\"fixed-case\">AW<\/jats:styled-content>) sebum and <jats:styled-content style=\"fixed-case\">AW<\/jats:styled-content> density of three areas of face were calculated. Statistical analysis was performed according to age and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no differences in the mean <jats:styled-content style=\"fixed-case\">AW<\/jats:styled-content> sebum level between the gender and age groups. Male has higher <jats:styled-content style=\"fixed-case\">AW<\/jats:styled-content> density of acne lesions than female at the O zone. The mean <jats:styled-content style=\"fixed-case\">AW<\/jats:styled-content> density of acne lesions on the <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content> zone, U zone, and whole face showed decrease by age, but at the O zone, 21\u201330\u00a0years group showed the highest mean <jats:styled-content style=\"fixed-case\">AW<\/jats:styled-content> density of acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>Age\u2010 and gender\u2010matched patients do not represent the whole acne patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We suggested that the O zone is an independent facial zone, which showed a moderate\u2010to\u2010high sebum secreting area, maintained the acne lesions development by age, and predominated acne lesions in the male acne patients than female acne patients. Therefore, the O zone should be separated from the usual cosmetic T zone, and <jats:styled-content style=\"fixed-case\">NT<\/jats:styled-content> zone should replace the old T zone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12101","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T08:25:29Z","timestamp":1377678329000},"page":"164-169","source":"Crossref","is-referenced-by-count":11,"title":["Novel facial cosmetic area \u2018O zone\u2019 shows unique characteristics in sebum excretion and acne lesion distribution"],"prefix":"10.1111","volume":"20","author":[{"given":"Sung Hwan","family":"Youn","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine and Seoul National University Bundang Hospital Seongnam Gyeonggi Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine and Seoul National University Bundang Hospital Seongnam Gyeonggi Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Woo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine and Seoul National University Bundang Hospital Seongnam Gyeonggi Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Ri","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine and Seoul National University Bundang Hospital Seongnam Gyeonggi Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Young","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine and Seoul National University Bundang Hospital Seongnam Gyeonggi Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Woong","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine and Seoul National University Bundang Hospital Seongnam Gyeonggi Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2005.00119.x"},{"key":"e_1_2_7_3_1","first-page":"690","volume-title":"Fitzpatrick's dermatology in general medicine","author":"Zaenglein A","year":"2008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.03.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06794.x"},{"key":"e_1_2_7_6_1","article-title":"Facial sebum affects the development of acne, especially the distribution of inflammatory acne","author":"Choi CW","year":"2011","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10598.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-006-0666-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.12.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08495.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2010.06.008"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12101","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:02:44Z","timestamp":1696176164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,28]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/srt.12101"],"URL":"https:\/\/doi.org\/10.1111\/srt.12101","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,28]]}}}