{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:36:19Z","timestamp":1791293779670,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,9,16]],"date-time":"2013-09-16T00:00:00Z","timestamp":1379289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Purpose<\/jats:title>To explore the application of optical coherence tomography (OCT<\/jats:styled-content>) imaging of basal cell carcinomas (BCC<\/jats:styled-content>) and actinic keratosis (AK<\/jats:styled-content>) before, during and after imiquimod treatment and the ability of OCT<\/jats:styled-content> to predict treatment outcome.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study subjects were 20 patients with biopsy\u2010verified BCC<\/jats:styled-content> (9) or AK<\/jats:styled-content> (11). Patients were OCT<\/jats:styled-content>\u2010scanned before, after 1 and 4\u00a0weeks of imiquimod treatment and after 3 months. Lesions were identified clinically and with OCT<\/jats:styled-content>. Thickness and morphology of the lesions were recorded at each visit. Any remaining lesions were biopsied at follow\u2010up.<\/jats:p><\/jats:sec>Results<\/jats:title>Complete data sets were available for 16 patients (8 women and 8 men aged 52\u201382\u00a0years), four in\u2010compliant patients were excluded. OCT<\/jats:styled-content> identified all lesions. Previously suggested OCT<\/jats:styled-content>\u2010criteria identified 5\/8 BCC<\/jats:styled-content>s. Crusting, ulceration and active treatment significantly reduced image quality. All BCC<\/jats:styled-content>s cleared, but at follow\u2010up residual structures were seen clinically in 4 cases. OCT<\/jats:styled-content> and histology both ruled out residual BCC<\/jats:styled-content>. For AK<\/jats:styled-content>s significant thinning occurred after 1\u00a0week of treatment (P<\/jats:italic>\u00a0=\u00a00.04). Imiquimod cleared 2\/8 AK<\/jats:styled-content>s, and significantly decreased the thickness of all lesions (P<\/jats:italic>\u00a0=\u00a00.02).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>OCT<\/jats:styled-content> could identify superficial BCC<\/jats:styled-content> and AK<\/jats:styled-content> before treatment. Monitoring during imiquimod treatment revealed impaired image quality most likely caused by inflammation, crusting and ulceration. On follow\u2010up, OCT<\/jats:styled-content> showed thinning of AK<\/jats:styled-content>s indicating effect of treatment. All treated BCC<\/jats:styled-content>s cleared, but where residual tissue was suspected clinically this could be ruled out by OCT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12102","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T13:50:33Z","timestamp":1381240233000},"page":"170-176","source":"Crossref","is-referenced-by-count":57,"title":["Optical coherence tomography imaging of non\u2010melanoma skin cancer undergoing imiquimod therapy"],"prefix":"10.1111","volume":"20","author":[{"given":"C. A.","family":"Banzhaf","sequence":"first","affiliation":[{"name":"Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Themstrup","sequence":"additional","affiliation":[{"name":"Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"Ring","sequence":"additional","affiliation":[{"name":"Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mogensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. B. E.","family":"Jemec","sequence":"additional","affiliation":[{"name":"Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61196-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10830.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-78574-5_36"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70261-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06486.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.11.066"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33251.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/16.6.619"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00827.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.09003.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2006.11.012"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20573"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01164.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.03.013"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2004.00038.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/153303460300200605"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2001.007001001.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201100006"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.05.030"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.12.1542-a"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042728-200507000-00011"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:02:52Z","timestamp":1696176172000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,16]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/srt.12102"],"URL":"https:\/\/doi.org\/10.1111\/srt.12102","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,16]]}}}