{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:29:10Z","timestamp":1790357350920,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T00:00:00Z","timestamp":1377648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Bullous pemphigoid is an autoimmune disease affecting prevalently the elder. <jats:italic>In vivo<\/jats:italic> reflectance confocal microscopy is a non\u2010invasive technique for real\u2010time imaging of the skin with cellular\u2010level resolution. No previous data has been reported about confocal microscopy of bullous pemphigoid. Aim of this preliminary study is the evaluation of the potential of <jats:italic>in vivo<\/jats:italic> reflectance confocal microscopy for real\u2010time, microscopical confirmation of clinical bullous pemphigoid diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of nine lesions from patients affected by pemphigoid underwent <jats:italic>in vivo<\/jats:italic> reflectance confocal microscopy before histological examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our preliminary study, confocal microscopy showed high grade of correspondence to histopathology. In particular, presence of sub\u2010epidermal cleft and variable amount of oedema of the upper dermis associated with inflammatory cells infiltration were seen as prevalent confocal features in the bullous lesions considered. Differently, in urticarial lesions, no specific features could be appreciated at confocal analysis beside the presence of signs of spongiosis and perivascular inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Confocal microscopy seems to be useful for <jats:italic>in vivo<\/jats:italic>, microscopical confirmation of the clinical suspect of bullous pemphigoid and for biopsy site selection in urticarial lesions to obtain a more significant specimen for histopathological examination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12105","type":"journal-article","created":{"date-parts":[[2013,8,28]],"date-time":"2013-08-28T08:25:29Z","timestamp":1377678329000},"page":"194-199","source":"Crossref","is-referenced-by-count":17,"title":["Real\u2010time, non\u2010invasive microscopic confirmation of clinical diagnosis of bullous pemphigoid using <i>in vivo<\/i> reflectance confocal microscopy"],"prefix":"10.1111","volume":"20","author":[{"given":"M.","family":"Ardig\u00f2","sequence":"first","affiliation":[{"name":"San Gallicano Dermatological Institute Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Agozzino","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatological Institute Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Amorosi","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatological Institute Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Moscarella","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatological Institute Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cota","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatological Institute Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"de Abreu","sequence":"additional","affiliation":[{"name":"Instituto de Dermatologia Professor Azulay \u2010 Santa Casa da Miseric\u00f3rdia do Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Berardesca","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatological Institute Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,28]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Pemphigus and Pemphigoid","author":"Lever WF","year":"1965"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-211-27377-8_4"},{"key":"e_1_2_7_4_1","first-page":"463","volume-title":"Dermatology","author":"Borradori 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