{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:50Z","timestamp":1787016170746,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T00:00:00Z","timestamp":1392249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Reflectance confocal microscopy (\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      ) has been recently shown to be effective for measuring the Demodex mite density.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To compare and demonstrate the advantages and disadvantages of standardized skin surface biopsy (\n                      <jats:styled-content style=\"fixed-case\">SSSB<\/jats:styled-content>\n                      ) and\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      for measuring the density of Demodex mites.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010eight patients (30 female, 18 male) and 47 healthy controls (30 female, 17 male) were enrolled in the study. The patients diagnoses were pityriasis folliculorum (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a040), papulopustulary rosecea (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a07) and erythema\u2010telengiectatic rosacea (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01). The area with the most intense erythema on the right cheek was selected for imaging with\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      (VivaScope 3000) and\n                      <jats:styled-content style=\"fixed-case\">SSSB<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010two patients demonstrated high Demodex density [(Dd)\u00a0&gt;\u00a05\u00a0mites\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ] with\n                      <jats:styled-content style=\"fixed-case\">SSSB<\/jats:styled-content>\n                      (85.7%).\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      identified demodicosis in 48 patients (100%). The mean Dd measured with\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      (409.8\u00a0\u00b1\u00a0209.2) was significantly higher than\n                      <jats:styled-content style=\"fixed-case\">SSSB<\/jats:styled-content>\n                      (15.33\u00a0\u00b1\u00a018.1) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). In the patients,\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      demonstrated the mean number of mites 40.90\u00a0\u00b1\u00a020.9 and 4.11\u00a0\u00b1\u00a06.4 in the controls per 10\u00a0mm\n                      <jats:sup>2<\/jats:sup>\n                      area. The corresponding mean number of 2.63\u00a0\u00b1\u00a00.77 mites was detected in the infested follicles per area of view compared to a mean of 0.77\u00a0\u00b1\u00a00.98 mites in the infested follicles in the controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Reflectance confocal microscopy is a fast, direct and noninvasive method for Demodex\u2010associated diseases and it is superior to\n                      <jats:styled-content style=\"fixed-case\">SSSB<\/jats:styled-content>\n                      for Demodex mite detection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.12137","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T00:17:26Z","timestamp":1392250646000},"page":"435-439","source":"Crossref","is-referenced-by-count":39,"title":["Reflectance confocal microscopy vs. standardized skin surface biopsy for measuring the density of Demodex mites"],"prefix":"10.1111","volume":"20","author":[{"given":"A.","family":"Turgut Erdemir","sequence":"first","affiliation":[{"name":"Dermatology Department Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Gurel","sequence":"additional","affiliation":[{"name":"Dermatology Department Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E.","family":"Koku Aksu","sequence":"additional","affiliation":[{"name":"Dermatology Department Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bilgin Karahalli","sequence":"additional","affiliation":[{"name":"Dermatology Department Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Incel","sequence":"additional","affiliation":[{"name":"Dermatology Department Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. S.","family":"Kutlu Hayto\u011flu","sequence":"additional","affiliation":[{"name":"Dermatology Department Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Falay","sequence":"additional","affiliation":[{"name":"Dermatology Department Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,13]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"214","article-title":"Hair follicle mites (Demodex spp.) of medical and veterinary concern","volume":"66","author":"Nutting WB","year":"1976","journal-title":"Cornell Vet"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155502753600795"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1979.04010030051021"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00261.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550510030069"},{"key":"e_1_2_5_7_1","first-page":"321","article-title":"Resistant scalp folliculitis secondary to Demodex infestation","volume":"76","author":"Sanfilippo AM","year":"2005","journal-title":"Cutis"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200403050-00019"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02455.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1971.tb06853.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09645.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10645.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.193"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11096.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652000000300012"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70065-2"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02471.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2003.08.007"},{"key":"e_1_2_5_19_1","first-page":"171","article-title":"Clinical applicability of in vivo reflectance confocal microscopy in dermatology","volume":"147","author":"Ulrich M","year":"2012","journal-title":"G Ital Dermatol Venereol"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03134.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.026"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12049"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2012.00615.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.05.034"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12137","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:02:02Z","timestamp":1694930522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,13]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/srt.12137"],"URL":"https:\/\/doi.org\/10.1111\/srt.12137","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,13]]}}}