{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:59:42Z","timestamp":1781276382823,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background\/objective<\/jats:title><jats:p>Reflectance confocal microscopy (<jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>) is a noninvasive, objective imaging technique that provides <jats:italic>in vivo<\/jats:italic>, high\u2010resolution skin imaging. We sought to assess epidermal and dermal changes associated with the psoriasis and its treatment with <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> before the treatment and at weeks 4 and 8 of the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>This is an investigator\u2010blinded, internal\u2010controlled, follow\u2010up study. A total of 25 patients with plaque psoriasis were included in the study. The <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> evaluation criteria were defined on the basis of the histopathological diagnostic criteria for psoriasis. The clinical severity of the psoriasis was evaluated using the Psoriasis Area Severity Index (<jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> findings which were correlated with the <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> can be used to follow up the patient's response to treatment have been identified as follows: the acanthosis, the number of spongiotic sites, the number of regular\/irregular honeycomb\u2010like sites, the number of epidermal inflammatory cells, the number of focal microabscesses, the total epidermal thickness, the number of nonedge dermal papillae, the length of the papillary dermis, the number of dermal inflammatory cells, and the vascularization in the papillary dermis (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study with a large group of patients to perform a noninvasive assessment with <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> of the response of psoriasis to different treatments: phototherapy, systemic and topical treatment. Micrometric and morphometric changes occurring in the psoriatic tissue during the 8\u2010week treatment period were identified by <jats:italic>in vivo <\/jats:italic><jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> in a noninvasive manner. <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> is capable of monitoring of treatment response in psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12150","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T11:50:03Z","timestamp":1392637803000},"page":"18-24","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of the response to treatment of psoriasis vulgaris with reflectance confocal microscopy"],"prefix":"10.1111","volume":"21","author":[{"given":"Y. K.","family":"Ba\u015faran","sequence":"first","affiliation":[{"name":"Sanliurfa Training and Research Hospital Dermatology Clinic Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"G\u00fcrel","sequence":"additional","affiliation":[{"name":"Istanbul Training and Research Hospital Dermatology Department Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. T.","family":"Erdemir","sequence":"additional","affiliation":[{"name":"Istanbul Training and Research Hospital Dermatology Department Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Turan","sequence":"additional","affiliation":[{"name":"Harran University School of Medicine Dermatology Department Sanliurfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Yurt","sequence":"additional","affiliation":[{"name":"Gumushane State Hospital Dermatology Clinic Gumushane Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. S.","family":"Ba\u011fci","sequence":"additional","affiliation":[{"name":"Istanbul Training and Research Hospital Dermatology Department Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12954-6"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2005.01.009"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06502.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.08.003"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.08.005"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2003.08.007"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00690.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70151-9"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01420.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00309.x"},{"key":"e_1_2_5_12_1","first-page":"337","article-title":"Characterization of psoriasis in vivo by reflectance confocal microscopy","volume":"30","author":"Gonzalez S","year":"1999","journal-title":"J Med"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03134.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20575"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10988.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.05.044"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00822.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/9780203091562-3"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12150","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:50:52Z","timestamp":1695487852000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,17]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/srt.12150"],"URL":"https:\/\/doi.org\/10.1111\/srt.12150","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,17]]}}}