{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:15:03Z","timestamp":1789823703928,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T00:00:00Z","timestamp":1409184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Sebum is thought to play an important role in acne vulgaris and sebum excretion rate (<jats:styled-content style=\"fixed-case\">SER<\/jats:styled-content>) is often used as a marker of efficacy in acne studies. This study explored factors that could induce intra\u2010subject variability in <jats:styled-content style=\"fixed-case\">SER<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SER<\/jats:styled-content> was measured twice, 7 days apart, on the forehead of 40 healthy subjects. At each visit, the following parameters were also evaluated: serum androgen levels, 5\u2010alpha\u2010reductase type I gene expression, forehead temperature, sleep habits, diet, facial washing routine, and <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a positive correlation between the time subjects fell asleep on Day 0 and the change in <jats:styled-content style=\"fixed-case\">SER<\/jats:styled-content> for the left (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.010; <jats:italic>R<\/jats:italic>\u00a0=\u00a00.402) and right sides (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002; <jats:italic>R<\/jats:italic>\u00a0=\u00a00.467) of the forehead. There was a significant inverse correlation between <jats:styled-content style=\"fixed-case\">SER<\/jats:styled-content> and 5\u2010alpha\u2010reductase type 1 expression and between free testosterone levels and 5\u2010alpha\u2010reductase type 1 expression. In sub\u2010analyses performed on men and women, these correlations were only significant for women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Variations in sleep patterns, free testosterone, and 5\u2010alpha\u2010reductase type 1 activity are associated with changes in sebum excretion in women. This could explain some of the inter\u2010subject variability in <jats:styled-content style=\"fixed-case\">SER<\/jats:styled-content> measured between visits in clinical studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12155","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T06:23:24Z","timestamp":1409207004000},"page":"47-53","source":"Crossref","is-referenced-by-count":13,"title":["Changes in serum free testosterone, sleep patterns, and 5\u2010alpha\u2010reductase type I activity influence changes in sebum excretion in female subjects"],"prefix":"10.1111","volume":"21","author":[{"given":"R.","family":"Bissonnette","sequence":"first","affiliation":[{"name":"Innovaderm Research Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Risch","sequence":"additional","affiliation":[{"name":"Innovaderm Research Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. J.","family":"McElwee","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Marchessault","sequence":"additional","affiliation":[{"name":"Innovaderm Research Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bolduc","sequence":"additional","affiliation":[{"name":"Innovaderm Research Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nigen","sequence":"additional","affiliation":[{"name":"Innovaderm Research Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Maari","sequence":"additional","affiliation":[{"name":"Innovaderm Research Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"100","article-title":"Sebaceous gland lipids","volume":"11","author":"Stewart ME","year":"1992","journal-title":"Semin Dermatol"},{"key":"e_1_2_6_3_1","first-page":"369","article-title":"Sebutape: a device for visualizing and measuring human sebaceous secretion","volume":"37","author":"Kligman AM","year":"1986","journal-title":"J Cosmet Sci"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701243"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02146.x"},{"key":"e_1_2_6_6_1","volume-title":"Nutrition Data System for Research (NDSR)","author":"Nutrition Coordinating Center, University of Minnesota","year":"2012"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2012.00645.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.1995.tb00111.x"},{"key":"e_1_2_6_9_1","first-page":"221","article-title":"An improved procedure for quantitative analysis of sebum production using Sebutape\u00ae","volume":"45","author":"Pagnoni A","year":"1994","journal-title":"J Cosmet Sci"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247853"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1081\/CBI-100101052"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420521003778773"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S1609"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/07420529309064489"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2001.25648"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(83)90117-6"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.12.2862"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12155","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:50:45Z","timestamp":1695487845000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,28]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/srt.12155"],"URL":"https:\/\/doi.org\/10.1111\/srt.12155","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,28]]}}}