{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T17:58:37Z","timestamp":1779127117651,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Background\/purpose<\/jats:title><jats:p>Washing the face with a mild cleanser is generally recommended for acne care. Occasionally, the general public has the misconception that acne is exacerbated by cleansers and furthermore it has concerns about inducing skin irritation and xerosis by intensive washing. Recently, we developed a new cleanser based on sodium laureth carboxylate and alkyl carboxylates (<jats:styled-content style=\"fixed-case\">AEC<\/jats:styled-content>\/soap) that cleans sebum well without penetrating the stratum corneum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We designed a controlled clinical trial conducted on adult Japanese males with moderate or less acne. Twenty subjects washed their faces with <jats:styled-content style=\"fixed-case\">AEC<\/jats:styled-content>\/soap base cleanser twice a day for 4\u00a0weeks. Assessment of the efficacy was conducted prior to the start of the study, and at the end of weeks 2 and 4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant improvement of the acne was observed within 2\u00a0weeks, and acne lesions were not detectable in 25% of the subjects at week 4. Sebum secretion levels on the skin significantly increased on the forehead, but significantly decreased on the cheek which correlated with the improvement. No complaints of dryness or irritation occurred during the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Washing the face twice a day with facial cleanser based on <jats:styled-content style=\"fixed-case\">AEC<\/jats:styled-content>\/soap is an effective care for moderate or less grade facial acne.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12183","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T14:15:56Z","timestamp":1407939356000},"page":"247-253","source":"Crossref","is-referenced-by-count":12,"title":["Effects of washing of the face with a mild facial cleanser formulated with sodium laureth carboxylate and alkyl carboxylates on acne in Japanese adult males"],"prefix":"10.1111","volume":"21","author":[{"given":"K.","family":"Isoda","sequence":"first","affiliation":[{"name":"Department of Dermatology Mie University Graduate School of Medicine Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Takagi","sequence":"additional","affiliation":[{"name":"Kao Corporation Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Endo","sequence":"additional","affiliation":[{"name":"Kao Corporation Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Miyaki","sequence":"additional","affiliation":[{"name":"Kao Corporation Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Kao Corporation Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Umeda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mie University Graduate School of Medicine Mie Japan"},{"name":"KSK Laboratories Inc Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Umeda\u2010Togami","sequence":"additional","affiliation":[{"name":"KSK Laboratories Inc Mie Japan"},{"name":"Graduate School of Medicine Translational Medical Science Mie University Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mie University Graduate School of Medicine Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00890.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12676718"},{"key":"e_1_2_8_4_1","first-page":"44","article-title":"The pathogenesis of acne","volume":"13","author":"Knor T","year":"2005","journal-title":"Acta Dermatovenerol Croat"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06794.x"},{"key":"e_1_2_8_6_1","first-page":"551","article-title":"Efficacy of 4 percent chlorhexidine gluconate skin cleanser in the treatment of acne vulgaris","volume":"39","author":"Stoughton RB","year":"1987","journal-title":"Cutis"},{"issue":"2","key":"e_1_2_8_7_1","first-page":"S2","article-title":"Emerging topical antimicrobial options for mild\u2010to\u2010moderate acne: a review of the clinical evidence","volume":"7","author":"Rosso J","year":"2008","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.77542"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.1977.tb07439.x"},{"key":"e_1_2_8_10_1","first-page":"264","article-title":"Comparison of a salicylic acid cleanser and a benzoyl peroxide wash in the treatment of acne vulgaris","volume":"11","author":"Shalita AR","year":"1989","journal-title":"Clin Ther"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/0128071-200910001-00001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2003.12.006"},{"key":"e_1_2_8_13_1","unstructured":"OzawaT MiyakiM.Skin cleanser composition. 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