{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T01:12:26Z","timestamp":1726449146687},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T00:00:00Z","timestamp":1414108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The characteristic vascular patterns of nonpigmented skin tumors have been established by dermoscopy. Recently, <jats:italic>in vivo<\/jats:italic> reflectance confocal microscopy (<jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>) has become an established method for the noninvasive examination of skin tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Determination of the value of <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> on the vascularity of nonpigmented skin tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and twenty two tumoral lesions have been evaluated by <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> in terms of their vascular structures. They were classified in five groups as basal cell carcinoma (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>), seborrheic keratosis (<jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>), squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>)\/keratoacanthoma, actinic keratosis (<jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>)\/Bowen disease and others. Vascular morphologies were investigated as curved linear, straight linear, branching, tubular\/canalicular, round and polymorphic vessels in six types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>Relatively, small number of patients with some tumor subgroups is limitation. Larger prospective studies are required before firm conclusions can be drawn.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Excellent compliance was obtained in interobserver analysis. Branching vessels had a high predictive value for basal cell carcinoma (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>) with <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Also vascular polymorphism was more frequently (69.4%) seen in malignant nonpigmented tumors (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) than benign nonpigmented tumors (30.6%). Furthermore, vessels with opposite flows had high predictive value for malignant tumors (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) compared with benign tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vascular properties can be evaluated in the diagnosis of nonpigmented tumoral skin lesions via <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12197","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T09:03:22Z","timestamp":1414141402000},"page":"333-339","source":"Crossref","is-referenced-by-count":12,"title":["Vascular patterns of nonpigmented tumoral skin lesions: confocal perspectives"],"prefix":"10.1111","volume":"21","author":[{"given":"P.","family":"Incel","sequence":"first","affiliation":[{"name":"Istanbul Training and Research Hospital Department of Dermatology Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. S.","family":"Gurel","sequence":"additional","affiliation":[{"name":"Istanbul Training and Research Hospital Department of Dermatology Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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