{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:35:30Z","timestamp":1778704530546,"version":"3.51.4"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T00:00:00Z","timestamp":1421020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Background<\/jats:title>Staphylococcal scalded skin syndrome (SSSS<\/jats:styled-content>) and toxic epidermal necrolysis (TEN<\/jats:styled-content>) both present with acute onset, high morbidity and significant mortality. Rapid diagnosis is therefore of importance. The aim of this study was to investigate and compare the presentation of these diseases using optical coherence tomography (OCT<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Two male patients with bullous diseases, SSSS<\/jats:styled-content> and TEN<\/jats:styled-content>, respectively, were photographed digitally, examined using dermoscopy, OCT<\/jats:styled-content> scanned and subsequently biopsied in the said order.<\/jats:p><\/jats:sec>Results<\/jats:title>The bullous skin was visualized by OCT<\/jats:styled-content> showing two distinct images: the SSSS<\/jats:styled-content>\u2010patient displayed superficial hyporefletive flaccid structures with a split high in the thickened (0.51\u00a0mm vs. 0.12\u00a0mm) epidermis while the TEN<\/jats:styled-content>\u2010patient demonstrated a larger hyporeflective ovoid structure with a split right below the thickened epidermis (0.18\u00a0mm vs. 0.06\u00a0mm).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These findings suggest that there is a potential for the application of OCT<\/jats:styled-content> scanning in the acute phase of SSSS<\/jats:styled-content> and TEN<\/jats:styled-content> in order to distinguish them for a faster diagnosis and better management and treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12200","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T16:11:41Z","timestamp":1421079101000},"page":"363-365","source":"Crossref","is-referenced-by-count":3,"title":["A case report of differentiating staphylococcal scalded skin syndrome and toxic epidermal necrolysis by optical coherence tomography"],"prefix":"10.1111","volume":"21","author":[{"given":"A. A.","family":"Hussain","sequence":"first","affiliation":[{"name":"Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"Banzhaf","sequence":"additional","affiliation":[{"name":"Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Themstrup","sequence":"additional","affiliation":[{"name":"Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. L.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Pathology Roskilde Hospital University of Copenhagen Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. B. E.","family":"Jemec","sequence":"additional","affiliation":[{"name":"Department of Dermatology Roskilde Hospital University of Copenhagen Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200304030-00003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.05.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.05.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02917.x"},{"key":"e_1_2_7_6_1","first-page":"188","article-title":"Staphylococcal Scalded Skin Syndrome: Criteria for Differential Diagnosis from Lyell's Syndrome. Two Cases in Adult Patients","volume":"19","author":"Napoli B","year":"2006","journal-title":"Ann Burns Fire Disasters"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000118508"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-011-1152-x"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12200","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:24:26Z","timestamp":1695540266000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,12]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/srt.12200"],"URL":"https:\/\/doi.org\/10.1111\/srt.12200","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,12]]}}}