{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:29:50Z","timestamp":1789122590286,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The majority of tattoo reactions are affiliated to red pigmented areas and often suspected to be allergic in nature. A sizeable series of biopsies of such reactions has not previously been performed. The aim of this study was to type and grade epidermal and dermal changes in tattoo reactions to red\/red nuances by microscopy and immunochemistry relevant for the assessment of a possible allergic pathomechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin biopsies were taken from red tattoo reactions, graded by conventional microscopy and stained for T and B\u2010lymphocytes, Langerhans cells, macrophages and tumour necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>)\u2010\u03b1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 19 biopsies from 19 patients. The culprit colours were red\/pink (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) and purple\/bordeaux (<jats:italic>n<\/jats:italic>\u00a0=\u00a04). Interface dermatitis was clearly the lead pathology found in 78% of samples, overlapped with granulomatous (in 32%) and pseudolymphomatous reaction patterns (in 32%). Epidermal hyperkeratosis (in 89%) was common as was leakage of red pigment across the dermo\u2010epidermal junction, with transepidermal elimination (in 28%). The dermal cellular infiltration was dominated by T\u2010lymphocytes (in 100%), Langerhans cells (in 95%) and macrophages (in 100%). <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 was common.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The predominant histological pattern of chronic tattoo reactions in red\/red nuances is interface dermatitis. T\u2010lymphocytes and Langerhans cells are increased suggesting an allergic pathomechanism. <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 may contribute to reactions. In many cases, overlapping reactive patterns were identified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12213","type":"journal-article","created":{"date-parts":[[2015,5,30]],"date-time":"2015-05-30T02:14:24Z","timestamp":1432952064000},"page":"449-458","source":"Crossref","is-referenced-by-count":30,"title":["Histopathology and immune histochemistry of red tattoo reactions"],"prefix":"10.1111","volume":"21","author":[{"given":"T.","family":"H\u00f8gsberg","sequence":"first","affiliation":[{"name":"Department of Dermatology Bispebjerg University Hospital Copenhagen NV Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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