{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:26:46Z","timestamp":1768685206069,"version":"3.49.0"},"reference-count":67,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T00:00:00Z","timestamp":1433289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>We hypothesized that reported age\u2010related shifts in skin water from less\u2010to\u2010more mobile states would result in increased skin tissue dielectric constant (<jats:styled-content style=\"fixed-case\">TDC<\/jats:styled-content>) values as <jats:styled-content style=\"fixed-case\">TDC<\/jats:styled-content> values depend strongly on water content and state. One aim was to test this hypothesis. Further, as skin\u2010to\u2010fat <jats:styled-content style=\"fixed-case\">TDC<\/jats:styled-content> values are used as a tool for edema and lymphedema assessment, a second aim was to establish reference values suitable for young and older women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TDC<\/jats:styled-content> was measured bilaterally on volar forearm skin in young (20\u201340\u00a0years) and older (\u226560\u00a0years) women. There were four groups with 50, 50, 100, and 50 subjects per age group measured to depths of 0.5, 1.5, 2.5, and 5.0\u00a0mm, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For each age group, <jats:styled-content style=\"fixed-case\">TDC<\/jats:styled-content> values decreased with increasing depth (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). <jats:styled-content style=\"fixed-case\">TDC<\/jats:styled-content> values at 0.5 and 1.5\u00a0mm were greater for older women (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). At 2.5\u00a0mm, there was no age\u2010group difference (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.108). At 5.0\u00a0mm the direction of the difference reversed with older <jats:styled-content style=\"fixed-case\">TDC<\/jats:styled-content> values less than the younger (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results are consistent with age\u2010related shifts in water state from less\u2010to\u2010more mobile and explain depth\u2010dependence differences between age groups. Data also give age\u2010related <jats:styled-content style=\"fixed-case\">TDC<\/jats:styled-content> reference values for assessing local edematous or lymphedematous states.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12249","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T02:11:28Z","timestamp":1433383888000},"page":"189-195","source":"Crossref","is-referenced-by-count":20,"title":["Age\u2010related differences in tissue dielectric constant values of female forearm skin measured noninvasively at 300\u00a0MHz"],"prefix":"10.1111","volume":"22","author":[{"given":"H. N.","family":"Mayrovitz","sequence":"first","affiliation":[{"name":"College of Medical Sciences Nova Southeastern University Ft. Lauderdale FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Singh","sequence":"additional","affiliation":[{"name":"College of Medical Sciences Nova Southeastern University Ft. 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