{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T10:38:47Z","timestamp":1720435127369},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,7]],"date-time":"2016-02-07T00:00:00Z","timestamp":1454803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Multiphoton laser tomography (<jats:styled-content style=\"fixed-case\">MPT<\/jats:styled-content>) is a non\u2010invasive technique that allows imaging of skin <jats:italic>in vivo<\/jats:italic> with very high spatial resolution and contrast. Previous work of our group has demonstrated that known morphological changes due to erythematogenic ultraviolet B (<jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>) irradiation may be imaged <jats:italic>in vivo<\/jats:italic> by <jats:styled-content style=\"fixed-case\">MPT<\/jats:styled-content>. The present work investigated if morphological skin changes known from experimental erythematogenic <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> irradiation are also demonstrable in the course of a standard phototherapy regime that implies suberythematogenic doses of narrow band <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen patients with psoriasis vulgaris receiving a narrow band phototherapy were included. A test field and a light\u2010protected control field were measured with the multiphoton tomograph DermaInspect<jats:sup>\u00ae<\/jats:sup> at four time points: at baseline, the next day, after 3 days and at the day of the last exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the course of the <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> phototherapy, spongiosis and pleomorphy as parameters of inflammation and cellular damage did not show significant changes. By contrast, an adaptive skin reaction with significant changes of keratosis and pigmentation was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MPT<\/jats:styled-content> is a suitable technique for the investigation of qualitative and quantitative skin changes after <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> irradiation. After suberythematogenic <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> irradiation, photoadaptive skin changes, but no cellular damage can be observed with <jats:styled-content style=\"fixed-case\">MPT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12284","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T06:19:10Z","timestamp":1454912350000},"page":"437-442","source":"Crossref","is-referenced-by-count":3,"title":["Epidermal changes during <scp>UVB<\/scp> phototherapy assessed by multiphoton laser tomography"],"prefix":"10.1111","volume":"22","author":[{"given":"M. J.","family":"Koehler","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Jena Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kellner","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Jena Jena Germany"},{"name":"ENT Department University Hospital Leipzig Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kaatz","sequence":"additional","affiliation":[{"name":"Department of Dermatology SRH Waldklinikum Gera Gera Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.\u2010C.","family":"Hipler","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Jena Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2010.00437.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.200710022"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.18.007857"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.1577349"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01405.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.31.002879"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2009.00372.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2011.00522.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2009.00423.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2012.00750.x"},{"key":"e_1_2_6_12_1","first-page":"305","article-title":"Clinical study on the effects of a cosmetic product on dermal extracellular matrix components using a high\u2010resolution multiphoton tomograph","volume":"16","author":"Bazin R","year":"2010","journal-title":"Skin Res Technol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01279.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00815.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.439"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01554.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.200910013"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201000074"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12168"},{"key":"e_1_2_6_20_1","first-page":"11","article-title":"Acute effects of ultraviolet radiation on the skin","volume":"9","author":"Soter NA","year":"1990","journal-title":"Semin Dermatol"},{"key":"e_1_2_6_21_1","first-page":"403","article-title":"Das Problem des Lichtschutzes und der Lichtgew\u00f6hnung","volume":"35","author":"Miescher G","year":"1930","journal-title":"Strahlentherapie"},{"key":"e_1_2_6_22_1","first-page":"601","article-title":"Die Schutzfunktionen der Haut gegen\u00fcber Lichtstrahlen","volume":"39","author":"Miescher G","year":"1931","journal-title":"Strahlentherapie"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12465094"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1562\/2005-12-21-RA-757"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12479237"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01478.x"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12284","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:27:51Z","timestamp":1695554871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,7]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/srt.12284"],"URL":"https:\/\/doi.org\/10.1111\/srt.12284","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,7]]}}}