{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:03:56Z","timestamp":1781327036954,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Engelhard Arzneimittel GmbH & Co. KG, Niederdorfelden, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Porphyrins are native fluorophores in the follicle openings, visible under ultraviolet\u2010A light. Acne severity might be associated with increased <jats:italic>Propionibacterium acnes<\/jats:italic> colonization and porphyrin production. Aim of this study was to investigate whether the parameter <jats:italic>fluorescence quantity<\/jats:italic> can be used to measure acne severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A validation study was conducted in 24 patients with acne using split\u2010face design. Acne severity was measured using Investigator Static Global Assessment scores and lesion counts. Reliability, construct validity and sensitivity to change in fluorescence quantity were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean baseline Investigator Static Global Assessment score was 2.7 (SD 0.1). Mean baseline fluorescence quantities were 24.8 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 4.0) on the cheek and 20.3 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 4.6) on the chin. On day 25, values ranged from 6.0 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 6.0) to 18.1 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 18.4) on the cheek and from 2.6 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 4.4) to 14.7 (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 16.2) on the chin. The intraclass correlation coefficients of fluorescence quantity ranged from 0.513 to 0.987. Effect sizes for fluorescence measurements were highest on the chin and cheek ranging from 0.24 to 0.77 and 0.32 to 0.75, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fluorescence quantity indicates acne severity, especially on the inner cheek and chin areas. Fluorescence quantity is reliable but is not as sensitive as manual lesion counting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12286","type":"journal-article","created":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T10:25:08Z","timestamp":1453717508000},"page":"451-459","source":"Crossref","is-referenced-by-count":12,"title":["Follicular fluorescence quantity to characterize acne severity: a validation study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3441-7982","authenticated-orcid":false,"given":"C.","family":"Richter","sequence":"first","affiliation":[{"name":"Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Department of Dermatology and Allergy Clinical Research Center for Hair and Skin Science Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Trojahn","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Department of Dermatology and Allergy 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