{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:34:47Z","timestamp":1775136887665,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,4]],"date-time":"2016-06-04T00:00:00Z","timestamp":1464998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Background<\/jats:title>Vesicobullous disorders are characterized by intraepidermal or subepidermal blistering resulting from different pathogenetic mechanisms. The diagnosis is generally based on clinical examination and semi\u2010invasive\/invasive procedures such as cytology and histopathology. In vivo<\/jats:italic> reflectance confocal microscopy (RCM<\/jats:styled-content>) is a non\u2010invasive technique for real\u2010time, en face imaging of the epidermis and upper dermis with high resolution close to conventional histopathology.<\/jats:p><\/jats:sec>Purpose<\/jats:title>To evaluate RCM<\/jats:styled-content> features of different vesicobullous diseases and correlate with cytologic and histopathologic examination.<\/jats:p><\/jats:sec>Methods<\/jats:title>Ten patients (6M\/4F, age range: 9\u201381 years) affected by blistering diseases, such as herpes simplex, herpes zoster, Kaposi's varicelliform eruption, pemphigus vulgaris, Hailey\u2013Hailey disease, bullous pemphigoid, and porphyria cutanea tarda were evaluated using a handheld RCM<\/jats:styled-content> device.<\/jats:p><\/jats:sec>Results<\/jats:title>In our study, a clear correlation between RCM<\/jats:styled-content> and Tzanck's test and\/or histopathology was observed. RCM<\/jats:styled-content> allowed in all cases an easy identification of the blister spaces and of the split levels, and in some cases specific features were detected, such as giant keratinocytes in herpes infections and acantholytic cells in pemphigus vulgaris and Hailey\u2013Hailey disease.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Reflectance confocal microscopy may support the clinical diagnosis of vesicobullous disorders and indicate to the physician the appropriate patient management and\/or the need for further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12289","type":"journal-article","created":{"date-parts":[[2016,6,4]],"date-time":"2016-06-04T15:30:05Z","timestamp":1465054205000},"page":"479-486","source":"Crossref","is-referenced-by-count":15,"title":["Reflectance confocal microscopy in the diagnosis of vesicobullous disorders: case series with pathologic and cytologic correlation and literature review"],"prefix":"10.1111","volume":"22","author":[{"given":"F.","family":"Lacarrubba","sequence":"first","affiliation":[{"name":"Dermatology Clinic University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"Verz\u00ec","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pippione","sequence":"additional","affiliation":[{"name":"Dermopathology Unit Gradenigo Hospital Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Micali","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12364"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13499"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12870"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.07.008"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120616"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2008.00332.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01279.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2011.00574.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2011.00581.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-011-0943-9"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2012.00662.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12105"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12146"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.08.050"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12289","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:28:45Z","timestamp":1695554925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,4]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/srt.12289"],"URL":"https:\/\/doi.org\/10.1111\/srt.12289","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,4]]}}}