{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T10:12:58Z","timestamp":1695636778207},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,5]],"date-time":"2016-06-05T00:00:00Z","timestamp":1465084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["8 UL1 TR000077\u201005"],"award-info":[{"award-number":["8 UL1 TR000077\u201005"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Infantile hemangiomas (<jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s) are benign vascular neoplasms with rapid capillary proliferation shortly after birth and slow involution with diminishing capillary proliferative activity, fibrosis, and fatty replacement over 7\u201310 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hemangiomas and contralateral control sites in 88 subjects were measured using a suction device, 6\u2010mm probe and 200 mbar negative pressure. Mechanical properties were assessed vs. controls and effects of body site, depth, clinical stage, histology diagnosis, and time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Biological elasticity, overall elasticity, net elasticity, total recovery, and elastic recovery were lower for <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> vs. controls (<jats:italic>P<\/jats:italic> &lt; 0.001). <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> total deformation, elastic deformation, viscoelastic creep, and residual deformation were higher than controls (<jats:italic>P<\/jats:italic> &lt; 0.001). Involuting <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s had lower viscoelasticity than proliferating and stable lesions (<jats:italic>P<\/jats:italic> &lt; 0.001) and lower viscoelastic creep than stable <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content>s (<jats:italic>P<\/jats:italic> = 0.04). <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> viscoelasticity was higher at 2.3 than 12.9, 23.7, and 61.0 months and at 4.9 and 8.1 than 61.0 months. <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> elastic recovery varied by body site with larger differences vs. control for abdomen and leg. Elastic recovery differences from control were smaller at younger vs. older ages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Measurement of biomechanical properties may be useful to characterize <jats:styled-content style=\"fixed-case\">IH<\/jats:styled-content> progression and treatment response in clinical settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12290","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T04:52:47Z","timestamp":1465188767000},"page":"487-496","source":"Crossref","is-referenced-by-count":4,"title":["Biomechanical properties of infantile hemangiomas: clinical stage and effect of age"],"prefix":"10.1111","volume":"22","author":[{"given":"M. O.","family":"Visscher","sequence":"first","affiliation":[{"name":"Skin Sciences Program Division of Plastic Surgery Cincinnati Children's Hospital Medical Center Cincinnati OH USA"},{"name":"Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"Burkes","sequence":"additional","affiliation":[{"name":"Skin Sciences Program Division of Plastic Surgery Cincinnati Children's Hospital Medical Center Cincinnati OH USA"},{"name":"Cincinnati Children's Hospital Medical Center Cincinnati OH USA"},{"name":"James L. Winkle College of Pharmacy University of Cincinnati Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Adams","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati OH USA"},{"name":"Hemangioma and Vascular Malformation Center Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Cincinnati Children's Hospital Medical Center Cincinnati OH USA"},{"name":"Hemangioma and Vascular Malformation Center Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. R.","family":"Wickett","sequence":"additional","affiliation":[{"name":"James L. Winkle College of Pharmacy University of Cincinnati Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2006.02.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820530902805438"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-0005(99)80041-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198203000-00002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S146239940700052X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3683"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2767"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2006.12.003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2010.07.008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0413"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198207000-00041"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02594082"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13905"},{"key":"e_1_2_6_15_1","first-page":"335","volume-title":"Handbook of non\u2010invasive methods and the skin","author":"Barel AO","year":"1995"},{"key":"e_1_2_6_16_1","first-page":"91","volume-title":"Biioengineering of the skin biomechanics","author":"Berndt U","year":"2001"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/9781420003307-79"},{"key":"e_1_2_6_18_1","first-page":"47","article-title":"Stretching the skin surface: skin elasticity","volume":"116","author":"Wicket RR","year":"2001","journal-title":"Cosmetics and Toiletries"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200011000-00024"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.1996.tb00145.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.1997.tb00170.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0909-725X.2006.00135.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181a65c59"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3828"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246472"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00375720"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb07282.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02451.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asj.2008.07.011"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2014.01.017"},{"key":"e_1_2_6_31_1","first-page":"509","article-title":"Doppler ultrasound and strain elastography in the assessment of cutaneous melanoma: preliminary results","volume":"17","author":"Botar Jid C","year":"2015","journal-title":"Medical ultrasonography"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2007.00229.x"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12290","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:28:58Z","timestamp":1695554938000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,5]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/srt.12290"],"URL":"https:\/\/doi.org\/10.1111\/srt.12290","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,5]]}}}