{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:37Z","timestamp":1787016097354,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:00:00Z","timestamp":1465344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"\n Background<\/jats:title>\n Acne vulgaris is a common disease of the pilosebaceous unit. The aim of the study was to evaluate compartment\u2010specific treatment action through the microscopic non\u2010invasive imaging of skin changes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Mild\u2010moderate acne patients, that were prescribed a topical anti\u2010acne product, were followed by clinical and reflectance confocal microscopy (\n RCM<\/jats:styled-content>\n ) imaging every 14 days to 6 weeks. Mean and standard deviation of the scores were analyzed for each time point.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n After 2 weeks, the\n RCM<\/jats:styled-content>\n count of papules\/pustules and the\n RCM<\/jats:styled-content>\n scores of exocytosis and dermal inflammation, decreased substantially. After 4 weeks, the\n RCM<\/jats:styled-content>\n number of comedos was reduced. After 6 weeks, the number of regular follicles increased, while the infundibula with thickened bright border decreased significantly.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The progressive reduction in the clinical scores was correlated with the improvement of the\n RCM<\/jats:styled-content>\n parameters.\n RCM<\/jats:styled-content>\n study of acne skin showed a different timing for inflammatory and hyperkeratotic components to achieve a significant reduction during topical therapy with the association of retinoid and antibacterial molecules. The microscopic changes observed showed the regularization of the skin and the improvement of acne related features.\n RCM<\/jats:styled-content>\n may represent a useful tool for the objective assessment of treatment efficacy and individual response evaluation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/srt.12298","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T07:54:29Z","timestamp":1465372469000},"page":"36-40","source":"Crossref","is-referenced-by-count":30,"title":["In vivo<\/i>\n monitoring of topical therapy for acne with reflectance confocal microscopy"],"prefix":"10.1111","volume":"23","author":[{"given":"M.","family":"Manfredini","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Farnetani","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mazzaglia","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ciardo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Bettoli","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Virgili","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pellacani","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04374.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.97666"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.3.280"},{"key":"e_1_2_7_6_1","first-page":"22","article-title":"In\u2010vivo effectiveness of 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