{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:32Z","timestamp":1740124352592,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The regrowth of a tumor after complete clinical response and the development of keratinocytic neoplasms while patients are still undergoing continuous vismodegib have stressed the importance of the accurate monitoring to detect recurrences earlier and ensure the best possible outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to determine the role of reflectance confocal microscopy (<jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>) in monitoring the response of locally advanced basal cell carcinoma (la<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>) to vismodegib and to discard secondary resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven patients presenting with nine la<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>, were prospectively included and their response to this drug was assessed by means of clinical examination, dermoscopy, and RCM. The study was conducted at the Melanoma Unit in Hospital Clinic of Barcelona, between June 2012 and March 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histologically confirmed lesion 10 mm or larger in diameter for which surgery was contraindicated and radiation therapy was inappropriate. The median patient age was 73 years and the most common histological type was infiltrating <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> allowed the identification of residual tumor in two lesions and to confirm complete response in the other four cases. Two patients developed new lesions within the tumor bed, they were assessed by <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> showing features of actinic keratosis which were confirmed by histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of <jats:italic>in vivo <\/jats:italic><jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> allowed the characterization of the dynamic morphologic changes in tumor response helping to better define partial response and to differentiate it from secondary resistance. Another interesting observation was the recognition of a phenomenon characterized by the development of keratinocytic neoplasms within the tumor bed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12332","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T06:38:52Z","timestamp":1477550332000},"page":"283-288","source":"Crossref","is-referenced-by-count":7,"title":["Tumor regrowth and development of keratinocytic neoplasms in patients under smoothened inhibition: <i>in vivo<\/i> assessment with reflectance confocal microscopy"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6738-2651","authenticated-orcid":false,"given":"I.","family":"Alarcon","sequence":"first","affiliation":[{"name":"Melanoma Unit Dermatology Department Hospital Clinic Barcelona Spain"},{"name":"Institut de Recerca Biom\u00e9dica August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Pasquali","sequence":"additional","affiliation":[{"name":"Department of Dermatology Pius Hospital de Valls Valls Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Malvehy","sequence":"additional","affiliation":[{"name":"Melanoma Unit Dermatology Department Hospital Clinic Barcelona Spain"},{"name":"Institut de Recerca Biom\u00e9dica August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER) ISCIII Barcelona Spain"},{"name":"Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Puig","sequence":"additional","affiliation":[{"name":"Melanoma Unit Dermatology Department Hospital Clinic Barcelona Spain"},{"name":"Institut de Recerca Biom\u00e9dica August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER) ISCIII Barcelona Spain"},{"name":"Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61196-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32835ff438"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113713"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.2354"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00690.x"},{"key":"e_1_2_8_7_1","first-page":"802","article-title":"In vivo reflectance confocal microscopy to monitor the response of lentigo maligna to imiquimod","volume":"170","author":"Alarcon I","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12052"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.8.1012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.172"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.4430"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.583"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.1798"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.419"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.04.067"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12332","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12332","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:21:05Z","timestamp":1695471665000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,27]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/srt.12332"],"URL":"https:\/\/doi.org\/10.1111\/srt.12332","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"type":"print","value":"0909-752X"},{"type":"electronic","value":"1600-0846"}],"subject":[],"published":{"date-parts":[[2016,10,27]]}}}