{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T23:18:23Z","timestamp":1776122303564,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T00:00:00Z","timestamp":1489622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["8 UL1 TR000077\u201005"],"award-info":[{"award-number":["8 UL1 TR000077\u201005"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Newborn infant skin changes after birth but studies have focused on the epidermal barrier. Dermal properties are relevant for care, but literature on postnatal changes is sparse. We further characterized skin maturational changes in lightness, color and response to biomechanical stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Normal skin sites from subsets of participants in a trial on the progression and stage of infantile hemangiomas were retrospectively examined. Standardized photographs were analyzed as L*, a*, and b* images. Biomechanics were measured with the Cutometer<jats:sup>\u00ae<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Color changed significantly with increasing age. Skin was darker and redder at 2.0 vs. 5.4, 8.5 and 12.8\u00a0months. Yellow color increased, with higher values at 12.8 vs. 2.0, 3.5 and 5.4\u00a0months. Chest tissue was consistently more elastic than arm and face sites, with significantly higher elasticity for the youngest and oldest age groups. Biological elasticity, elastic recovery, and total recovery were significantly greater for the oldest subjects. Viscoelasticity and elastic deformation were lower at 5.5 vs. 8.8 and 17.6\u00a0months. Arm viscoelastic creep was highest at 2.8\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Skin maturation continues into year two. Increasing elasticity and decreasing viscoelasticity may reflect increased collagen structure\/function. The findings have implications for prevention of skin injury associated with mechanical forces.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12369","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T04:22:41Z","timestamp":1489724561000},"page":"545-551","source":"Crossref","is-referenced-by-count":23,"title":["Infant skin maturation: Preliminary outcomes for color and biomechanical properties"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9266-4127","authenticated-orcid":false,"given":"M. O.","family":"Visscher","sequence":"first","affiliation":[{"name":"Skin Sciences Program Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"Burkes","sequence":"additional","affiliation":[{"name":"Skin Sciences Program Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"James L. Winkle College of Pharmacy University of Cincinnati  Cincinnati OH USA"},{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Adams","sequence":"additional","affiliation":[{"name":"Hemangioma and Vascular Malformation Center Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Hammill","sequence":"additional","affiliation":[{"name":"Hemangioma and Vascular Malformation Center Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. R.","family":"Wickett","sequence":"additional","affiliation":[{"name":"James L. 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