{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:05:30Z","timestamp":1760043930655,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T00:00:00Z","timestamp":1494979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Kagome Research Scholar Program"},{"DOI":"10.13039\/100012609","name":"Lewis B. and Dorothy Cullman Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012609","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Purpose<\/jats:title><jats:p>Severe alcohol intolerance characterized by flushing, headache, nausea, and tachycardia even after very modest oral alcohol consumption, is common among East Asians (Chinese, Japanese, Koreans) and has been associated with the accumulation of acetaldehyde resulting from genetic polymorphism of aldehyde dehydrogenase (<jats:styled-content style=\"fixed-case\">ALDH<\/jats:styled-content>). These individuals also display erythema of the skin in response to exposure to topical alcohol. We have recently observed that dietary phytochemicals such as sulforaphane can accelerate the disposal of acetaldehyde from cells and animals by inducing <jats:styled-content style=\"fixed-case\">ALDH<\/jats:styled-content>. The goal of this study was to quantify the erythema response of skin to topical alcohol exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The erythema response of the forearm skin of healthy Japanese with unusual alcohol sensitivity evoked by a range of very low doses of alcohol (2, 4, 8, and 16\u00a0\u03bcmol\/cm<jats:sup>2<\/jats:sup>) was determined by means of a chromometer, which measures <jats:italic>a<\/jats:italic>* values (red\u2010green scale).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The magnitude of the <jats:italic>a<\/jats:italic>* response (\u2206<jats:italic>a<\/jats:italic>*) to alcohol was time\u2010 and dose\u2010dependent, but differed considerably among individuals. It was much higher in those individuals who claimed to be alcohol intolerant, and \u2206<jats:italic>a<\/jats:italic>* was unrelated to the initial <jats:italic>a<\/jats:italic>* values of the skin prior to alcohol challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The \u2206<jats:italic>a<\/jats:italic>* index is suitable for the quantitative determination of topical alcohol\u2010induced erythema response, and the evaluation of effectiveness of protective strategies against erythema response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12376","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T08:22:38Z","timestamp":1495009358000},"page":"593-596","source":"Crossref","is-referenced-by-count":8,"title":["Quantification of skin erythema response to topical alcohol in alcohol\u2010intolerant East Asians"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6817-2314","authenticated-orcid":false,"given":"Y.","family":"Aoki","sequence":"first","affiliation":[{"name":"Lewis B. and Dorothy Cullman Chemoprotection Center Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. L.","family":"Wehage","sequence":"additional","affiliation":[{"name":"Lewis B. and Dorothy Cullman Chemoprotection Center Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Talalay","sequence":"additional","affiliation":[{"name":"Lewis B. and Dorothy Cullman Chemoprotection Center Department of Pharmacology and Molecular Sciences Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1537\/ase1911.99.123"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91172-7"},{"key":"e_1_2_6_4_1","first-page":"837","article-title":"Structural mutation in a major human aldehyde dehydrogenase gene results in loss of enzyme activity","volume":"34","author":"Impraim C","year":"1982","journal-title":"Amer J Human Gen"},{"key":"e_1_2_6_5_1","first-page":"1219","article-title":"Acetaldehyde metabolism in different aldehyde dehydrogenase\u20102 genotypes","volume":"152","author":"Enomoto N","year":"1991","journal-title":"Alcoholism Clin Exper Res"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.59.115"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0943"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(02)00552-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1985.tb05596.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.38.2.181"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408390903044081"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1996.tb01932.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21107"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000050"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyr026"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agt063"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.04.007"},{"key":"e_1_2_6_18_1","first-page":"872","article-title":"Innovative preparation of curcumin for improved oral bioavailability","volume":"43","author":"Sasaki H","year":"2011","journal-title":"Biol Pharmaceut Bull"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0773.2002.910302.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708710104"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2009.00404.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2007.00256.x"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:05:04Z","timestamp":1695488704000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,17]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/srt.12376"],"URL":"https:\/\/doi.org\/10.1111\/srt.12376","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"type":"print","value":"0909-752X"},{"type":"electronic","value":"1600-0846"}],"subject":[],"published":{"date-parts":[[2017,5,17]]}}}