{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T22:12:31Z","timestamp":1766441551567,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T00:00:00Z","timestamp":1494979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Acute radiation dermatitis (<jats:styled-content style=\"fixed-case\">ARD<\/jats:styled-content>) is a frequent complication after breast cancer radiotherapy and is usually assessed by semi\u2010quantitative clinical scores, which may be subject to inter\u2010observer variability. High\u2010frequency ultrasound imaging of the skin can reliably quantify thickness and edema in diseased skin. We aimed to compare the relative increase in dermal thickness of the irradiated zone in breast\u2010cancer patients undergoing radiotherapy, with clinical severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A consecutive series of patients undergoing treatment for breast cancer by lumpectomy and radiotherapy in a 6\u2010month period also underwent clinical and ultrasound evaluation of <jats:styled-content style=\"fixed-case\">ARD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 34 female patients 17 had grade 1 (group 1), 17 had grade 2 or grade 3 <jats:styled-content style=\"fixed-case\">ARD<\/jats:styled-content> (group 2). The mean relative increase in dermal thickness in irradiated skin (<jats:styled-content style=\"fixed-case\">RIDTIS<\/jats:styled-content>) was greater for group 2 than 1: 0.53 vs 0.29\u00a0mm (<jats:italic>P<\/jats:italic>=.023). On univariate analysis, <jats:styled-content style=\"fixed-case\">ARD<\/jats:styled-content> was associated with skin phototype, breast volume and <jats:styled-content style=\"fixed-case\">RIDTIS<\/jats:styled-content>, and on multivariable analysis, breast volume and age remained predictive of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with more severe dermatitis showed significantly increased dermal thickness. Dermal thickness is a quantitative variable that could help quantify the efficacy of drugs and improve the treatment of this disease in patients undergoing radiotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12378","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T08:22:39Z","timestamp":1495009359000},"page":"602-606","source":"Crossref","is-referenced-by-count":11,"title":["High\u2010frequency ultrasound quantification of acute radiation dermatitis: pilot study of patients undergoing radiotherapy for breast cancer"],"prefix":"10.1111","volume":"23","author":[{"given":"M.","family":"Garnier","sequence":"first","affiliation":[{"name":"Department of Dermatology CHRU Tours  Tours France"},{"name":"Department of Radiotherapy CHR Orl\u00e9ans  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Champeaux","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy CHR Orl\u00e9ans  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Laurent","sequence":"additional","affiliation":[{"name":"Department of Epidemiology CHRU Tours  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Boehm","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy CHR Orl\u00e9ans  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Briard","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy CHR Orl\u00e9ans  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Wachter","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy CHR Orl\u00e9ans  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Vaillant","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHRU Tours  Tours France"},{"name":"Inserm U930 Universit\u00e9 Fran\u00e7ois\u2010Rabelais de Tours  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Patat","sequence":"additional","affiliation":[{"name":"Inserm U930 Universit\u00e9 Fran\u00e7ois\u2010Rabelais de Tours  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Bens","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHR Orl\u00e9ans  Orl\u00e9ans France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5985-878X","authenticated-orcid":false,"given":"L.","family":"Machet","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHRU Tours  Tours France"},{"name":"Inserm U930 Universit\u00e9 Fran\u00e7ois\u2010Rabelais de Tours  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,17]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Breast Cancer Treatment (PDQ\u00ae):Health Professional Version. 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