{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:52:33Z","timestamp":1740124353880,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:00:00Z","timestamp":1496620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Medical practitioners have long associated the physical appearance of human fingernails with certain underlying health conditions due to their direct connection to the vascular system. The objective of this study was to demonstrate how human fingernails can potentially be used as a biomarker to determine the severity of a patient's reaction to chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Quantitative investigation of fingernails in patients undergoing taxane\u2010based chemotherapy was conducted using a high\u2010frequency 50 MHz ultrasound device in B\u2010mode in the form of a pilot study. Time\u2010of\u2010Flight (TOF) ultrasonic signal measurements were recorded longitudinally across fingernails over three time intervals; (before treatment, in the middle of treatment, and on the last day of treatment); a neuropathy assessment and photographs were also taken for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 17 patients were examined in this study with ages ranging from 35\u201069 years old with both weekly and biweekly chemotherapy regimens. Onycholysis and fingernail discoloration were observed in 8 of the 17 patients. White transverse lines and white lunula were observed on 4 of the 17 patients. Quantitative assessment revealed a TOF median decrease in fingernails during the first half of chemotherapy treatment; conversely, TOF median was found to have increased during the second half. Median TOF measurements at the end of treatment were found to return to approximately that of the baseline value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This was a novel application of ultrasound in fingernails as chemotherapy biomarkers and further studies should be considered to verify and expand on the results obtained in this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12385","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T04:12:50Z","timestamp":1496722370000},"page":"20-25","source":"Crossref","is-referenced-by-count":1,"title":["Investigation of a correlation between taxane\u2010based chemotherapy and the ultrasonic time\u2010of\u2010flight of human fingernails"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6278-3341","authenticated-orcid":false,"given":"R. 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T.","family":"Daabous","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic Imaging Research University of Windsor  Windsor ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Strumban","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic Imaging Research University of Windsor  Windsor ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. G.","family":"Maev","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic Imaging Research University of Windsor  Windsor ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000403346"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-1291-5_16"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03426.x"},{"key":"e_1_2_7_5_1","article-title":"Malignancy and cancer treatment\u2010related hair and nail changes","volume":"63","author":"Hinds G","year":"2008","journal-title":"Dermatol Clin"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3920\/978-90-8686-728-8_20"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.02.026"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1178"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4020-8823-0_28"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2008.01.017"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2001.007001060.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2009.03.018"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2011.645099"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008345613594"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1970.tb02205.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.04.024"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155208100450"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.01.006"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2009.03.020"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:14:02Z","timestamp":1695482042000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,5]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/srt.12385"],"URL":"https:\/\/doi.org\/10.1111\/srt.12385","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"type":"print","value":"0909-752X"},{"type":"electronic","value":"1600-0846"}],"subject":[],"published":{"date-parts":[[2017,6,5]]}}}