{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:34:45Z","timestamp":1766136885872,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Colgate-Palmolive"},{"name":"The Innovation Fund Denmark","award":["4107-00011A"],"award-info":[{"award-number":["4107-00011A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/purpose<\/jats:title><jats:p>Our objective was to assess epithelialization of suction blister lesions by optical coherence tomography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) and benchmark it to histology using epidermal thickness (<jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content>) as the primary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two healthy volunteers were recruited to Study 1 and 2. One 10\u2010mm suction blister was raised on each buttock, and the blister roof was excised. Lesions were covered with moisture\u2010retaining dressing. In Study 1, the lesions were <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>\u2010scanned on day 0 (D0), D2 and D4 and excised for histological examination. In Study 2, the progress of epithelialization and skin barrier function were monitored to D14.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> increased from D0 to D2 by 46\u00a0\u03bcm (<jats:italic>P<\/jats:italic>&lt;.001) and from D2 to D4 by 19\u00a0\u03bcm (<jats:italic>P<\/jats:italic>=.004). Compared with histology, <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> overestimated the presence of the epithelium (<jats:italic>P<\/jats:italic>&lt;.0001) and <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> on D4. Reliable measurements were obtained when the <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> of the lesions reached the <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> of the normal epidermis from D5\u2010D7 and onwards. The <jats:styled-content style=\"fixed-case\">ET<\/jats:styled-content> development was reflected in decreased transepidermal water loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found that the <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> technique was poorly discriminative with respect to the neoepithelium and the moist lesion surface material in the early postinjury period. In the later stages, <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> seemed valuable for estimating the advancement of epithelialization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12391","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T12:02:47Z","timestamp":1499428967000},"page":"65-72","source":"Crossref","is-referenced-by-count":17,"title":["Suction blister lesions and epithelialization monitored by optical coherence tomography"],"prefix":"10.1111","volume":"24","author":[{"given":"M.G.","family":"Ahlstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Dermatology and Copenhagen Wound Healing Center Bispebjerg Hospital University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.M.R.","family":"Gjerdrum","sequence":"additional","affiliation":[{"name":"Department of Pathology Zealand University Hospital  Roskilde 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