{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:33:09Z","timestamp":1782199989026,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T00:00:00Z","timestamp":1502064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/purpose<\/jats:title><jats:p>Hailey\u2010Hailey disease is a rare inherited acantholytic skin disorder characterized by heterogeneous clinical presentation. Its differential diagnosis might be wide, including other genodermatoses, inflammatory, and infectious skin diseases. Although histopathology remains as diagnostic gold standard, noninvasive techniques such as dermoscopy and reflectance confocal microscopy may assist clinical examination. Herein, we aim to further characterize the dermoscopic and reflectance confocal microscopic presentation of Hailey\u2010Hailey disease with histologic correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight patients with Hailey\u2010Hailey disease were consecutively recruited. All patients were examined using dermoscopy and reflectance confocal microscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all cases, dermoscopy enabled the visualization of polymorphous vessels, including glomerular and linear\u2010looped vessels, within a pink\u2010whitish background. Reflectance confocal microscopy revealed wide suprabasilar partial acantholysis and clefting, crusts, dilated papillae with tortuous vessels, and inflammatory cells. Dyskeratosis, uplocated papillae, and adnexal sparing were also observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although definite diagnosis was obtained by histopathology in all cases, dermoscopy and reflectance confocal microscopy allowed the identification of common features (even in cases with dissimilar clinical presentation) that may support an early diagnosis of Hailey\u2010Hailey disease, and its differentiation from other more frequent skin disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12394","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T07:42:42Z","timestamp":1502091762000},"page":"85-92","source":"Crossref","is-referenced-by-count":14,"title":["Dermoscopic and reflectance confocal microscopic presentation of Hailey\u2010Hailey disease: A case series"],"prefix":"10.1111","volume":"24","author":[{"given":"A.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital de Santa Maria  Lisbon Portugal"},{"name":"Centro Acad\u00e9mico de Medicina University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Arzberger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Pimentel","sequence":"additional","affiliation":[{"name":"Centro Acad\u00e9mico de Medicina University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. C.","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Centro Hospitalar de Lisboa Central  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Leal\u2010Filipe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de Santa Maria  Lisbon Portugal"},{"name":"Centro Acad\u00e9mico de Medicina University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2015.04.006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12021"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107620"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2544-7"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/71701"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2016.12.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13769"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13026"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2015.04.009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsi.2016.08.003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb00592.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.6880"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.05.020"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12503_suppl"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12146"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12289"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2012.00662.x"},{"key":"e_1_2_6_19_1","first-page":"2386","article-title":"In vivo confocal microscopy for diagnosis of melanoma and basal cell carcinoma using a two\u2010step method: analysis of 710 consecutive clinically equivocal cases","volume":"132","author":"Guitera P","year":"2012","journal-title":"J Invest"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-016-0141-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13238"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13499"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2016.05.011"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2012.06.012"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.04.066"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1999.tb01797.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.041"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.08.039"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12394","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:13:12Z","timestamp":1695481992000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,7]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/srt.12394"],"URL":"https:\/\/doi.org\/10.1111\/srt.12394","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,7]]}}}