{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:30:14Z","timestamp":1793046614908,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Skin biopsies only provide point\u2010in\u2010time data making longitudinal studies difficult. Using Dynamic optical coherence tomography (D\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) in vivo<jats:italic>,<\/jats:italic> non\u2010invasive imaging of the microvasculature becomes possible. The current <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> literature is almost exclusively based on qualitative information but quantitative data may offer additional advantages, for example, by reducing observer variation. The objective of this study was to evaluate the in vivo superficial distribution of blood vessels, defined as the surface\u2010to\u2010first\u2010vessel distance, in actinic keratosis, basal cell carcinoma, squamous cell carcinoma and normal skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>D\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> images of 52 histologically verified lesions and corresponding normal skin were included. The dataset consisted of 13 <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>, 22 <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> and 17 <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>. No tumour sub\u2010classification was done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The quantitative measurement of the surface\u2010to\u2010first\u2010vessel distance showed a significant difference between <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> and corresponding normal skin. Significant differences were also seen for <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>, and it is hypothesized that the measure may also be able to distinguish between <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> (borderline significant differences).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results could prove useful in discriminating between non\u2010melanoma skin cancer lesions and healthy skin and in making a specific diagnosis. It is suggested that collecting different quantitative measurements increases the utility of D\u2013<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> and makes the method less observer\u2010dependent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12399","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T19:53:23Z","timestamp":1501790003000},"page":"123-128","source":"Crossref","is-referenced-by-count":24,"title":["In vivo measurements of blood vessels\u2019 distribution in non\u2010melanoma skin cancer by dynamic optical coherence tomography \u2014 a new quantitative measure?"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0867-0725","authenticated-orcid":false,"given":"V.","family":"Sigsgaard","sequence":"first","affiliation":[{"name":"Department of Dermatology Zealand University Hospital University of Copenhagen  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Themstrup","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital University of Copenhagen  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Theut Riis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital University of Copenhagen  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital University of Copenhagen  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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