{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:20:36Z","timestamp":1777389636705,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Writing\/editorial support was funded by Meda, a Mylan company"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Erythema\u2010directed digital photography is a novel method for evaluating the efficacy and tolerability of topical acne treatments. Here, we describe three case reports in which erythema\u2010directed digital photography was used to evaluate acne before and after up to 12\u00a0weeks of treatment with clindamycin 1%\/tretinoin 0.025% (Clin\u2010RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Erythema\u2010directed digital photography was used to evaluate acne in three patients with mild\u2010to\u2010moderate facial acne, two of whom had refused to continue previous topical acne treatment (benzoyl peroxide 5% and clindamycin 1%\/benzoyl peroxide 5%) due to persistent irritation. Acne lesions and erythema were evaluated using standard clinical photography and erythema\u2010directed digital photography (VISIA\u2010CR<jats:sup>\u2122<\/jats:sup> system) before and after 8\u201012\u00a0weeks of treatment with Clin\u2010RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Erythema\u2010directed digital photography revealed background erythema from previous topical acne treatments that was not evident from standard clinical photographs and allowed a better visualization of both inflammatory and non\u2010inflammatory lesions. In all patients, there was a clear improvement in background erythema and a reduction in acne lesions following treatment with Clin\u2010RA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study has demonstrated for the first time that erythema\u2010directed digital photography can enhance the evaluation of the efficacy and tolerability of topical acne treatments. These cases show that Clin\u2010RA was associated with improved efficacy and tolerability vs previous treatments with topical monotherapy (benzoyl peroxide 5%) or a topical fixed\u2010dose combination (clindamycin 1%\/benzoyl peroxide 5%).<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12448","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T12:26:43Z","timestamp":1517401603000},"page":"440-444","source":"Crossref","is-referenced-by-count":14,"title":["Erythema\u2010directed digital photography for the enhanced evaluation of topical treatments for acne vulgaris"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5157-3939","authenticated-orcid":false,"given":"G.","family":"Micali","sequence":"first","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Dall'Oglio","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tedeschi","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Lacarrubba","sequence":"additional","affiliation":[{"name":"Dermatology Clinic University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00667.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.03.008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90680-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.1390s2048.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04416.x"},{"key":"e_1_2_7_8_1","first-page":"746","article-title":"Auto\u2010classification of acne lesions using multimodal imaging","volume":"12","author":"Patwardhan SV","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_9_1","first-page":"1312","article-title":"VISIA system: a possible tool in the cosmetic practice","volume":"13","author":"Goldsberry A","year":"2014","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2016.1157360"},{"key":"e_1_2_7_11_1","first-page":"436","article-title":"A novel cosmetic antifungal\/anti\u2010inflammatory topical gel for the treatment of mild to moderate seborrheic dermatitis of the face: an open\u2010label trial utilizing clinical evaluation and erythema\u2010directed digital photography","volume":"152","author":"Dall'Oglio F","year":"2017","journal-title":"G Ital Dermatol Venereol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2318-3"},{"key":"e_1_2_7_13_1","first-page":"30","article-title":"Improving treatment of erythematotelangiectatic rosacea with laser and\/or topical therapy through enhanced discrimination of its clinical features","volume":"9","author":"Micali G","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2014.2293"},{"key":"e_1_2_7_15_1","first-page":"607","article-title":"ZIANA study group. Clinical safety and efficacy studies of a novel formulation combining 1.2% clindamycin phosphate and 0.025% tretinoin for the treatment of acne vulgaris","volume":"6","author":"Schlessinger J","year":"2007","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13185"},{"key":"e_1_2_7_17_1","first-page":"405","article-title":"Clindamycin phosphate 1.2%\u2010 tretinoin 0.025% gel: vehicle characteristics, stability, and tolerability","volume":"81","author":"Rosso JQ","year":"2008","journal-title":"Cutis"},{"key":"e_1_2_7_18_1","first-page":"33","article-title":"Evaluation of a topical anti\u2010inflammatory\/antifungal combination cream in mild\u2010to\u2010moderate facial seborrheic dermatitis: an intra\u2010subject controlled trial examining treated vs. untreated skin utilizing clinical features and erythema\u2010directed digital photography","volume":"8","author":"Dall'Oglio F","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_19_1","first-page":"1422","article-title":"A double\u2010blind, randomized, bilateral comparison of skin irritancy following application of the combination acne products clindamycin\/tretinoin and benzoyl peroxide\/adapalene","volume":"11","author":"Goreshi R","year":"2012","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_20_1","first-page":"383","article-title":"Tolerability of clindamycin\/tretinoin gel vs. tretinoin microsphere gel and adapalene gel","volume":"8","author":"Leyden J","year":"2009","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.019"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.12448","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T01:04:26Z","timestamp":1694394266000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,31]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/srt.12448"],"URL":"https:\/\/doi.org\/10.1111\/srt.12448","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,31]]}}}