{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T02:45:51Z","timestamp":1788576351671,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703107 Aiyuan Guo"],"award-info":[{"award-number":["81703107 Aiyuan Guo"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Seborrheic keratosis (\n                      <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>\n                      ) is one of the most common skin tumors seen by dermatologists. It should be differentiated with many diseases, especially skin tumors. Reflectance confocal microscopy (\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      ) has been applied for evaluation of\n                      <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>\n                      . There are a few studies that describe the\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      of\n                      <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>\n                      . The aim of the study was to find\u00a0the challenge of diagnosing seborrheic keratosis by reflectance confocal microscopy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 390 patients with a clinical suspicious diagnosis of seborrheic keratosis were enrolled in this study, and lesions from each patient were imaged with\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      . Thirty\u2010seven of these patients performed a biopsy in order to be given a histological diagnosis. We retrospectively analyzed the outcomes of\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      diagnosis and histological diagnosis, and then found the\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      characteristics of biopsy\u2010proven lesions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      According to\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      images, 258 of 390 (66.2%) patients were diagnosed with\n                      <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>\n                      , 97 of 390 (24.9%) patients could not be diagnosed by the dermatologist according to\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      . Of all 37 biopsied lesions, 23 were\n                      <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>\n                      , 6 were actinic keratosis, 2 were basal cell carcinoma, and 2 were squamous cell carcinoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      It is challenge to diagnose seborrheic keratosis by reflectance confocal microscopy. It may due to the variable clinical and\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      appearances of\n                      <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>\n                      , and limited depth of\n                      <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/srt.12582","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T04:25:26Z","timestamp":1527135926000},"page":"663-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The challenge of diagnosing seborrheic keratosis by reflectance confocal microscopy"],"prefix":"10.1111","volume":"24","author":[{"given":"A.","family":"Guo","sequence":"first","affiliation":[{"name":"Department of 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