{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T08:29:02Z","timestamp":1768120142386,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009695","name":"Catholic Kwandong University","doi-asserted-by":"publisher","award":["CKURF\u2010201406830001"],"award-info":[{"award-number":["CKURF\u2010201406830001"]}],"id":[{"id":"10.13039\/501100009695","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Energy\u2010delivering devices can be used to induce thermal coagulation of the eccrine sweat glands for treating primary axillary hyperhidrosis (PAH<\/jats:styled-content>).<\/jats:p><\/jats:sec>Objective<\/jats:title>The objective of this study was to compare the efficacy and safety of invasive, bipolar radiofrequency (RF<\/jats:styled-content>) treatment for PAH<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A split\u2010axilla study was performed to compare the clinical outcomes of 0.5\u00a0MH<\/jats:styled-content>z, invasive, bipolar RF<\/jats:styled-content> treatment with treatment settings of a longer conduction time and lower power (LC<\/jats:styled-content>\/LP<\/jats:styled-content>) vs a shorter conduction time and higher power (SC<\/jats:styled-content>\/HP<\/jats:styled-content>) for treating PAH<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>The in vivo study revealed median hyperhidrosis disease severity scale scores of 1.5 (interquartile range [IQR<\/jats:styled-content>], 1\u20102) at 1\u00a0month and 1 (IQR<\/jats:styled-content>, 1\u20102) at 3\u00a0months after treatment with the LC<\/jats:styled-content>\/LP<\/jats:styled-content> setting, compared to baseline. Meanwhile, the other side of the axillae treated with the SC<\/jats:styled-content>\/HP<\/jats:styled-content> setting showed scores of 2 (IQR<\/jats:styled-content>, 2\u20102) at 1\u00a0month and 2 (IQR<\/jats:styled-content>, 1.25\u20102) at 3\u00a0months. Analysis via a linear mixed model revealed a significant interaction (group, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.011; time, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001; and group\u00a0\u00d7\u00a0time, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.048) between treatment group and time.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>PAH<\/jats:styled-content> can be effectively and safely treated with invasive, multilayered, multiple\u2010pass, 0.5\u2010MH<\/jats:styled-content>z, bipolar RF<\/jats:styled-content> treatment, particularly with LC<\/jats:styled-content>\/LP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12591","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T09:26:50Z","timestamp":1527067610000},"page":"30-39","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Split\u2010axilla comparison study of 0.5\u2010MHz, invasive, bipolar radiofrequency treatment using insulated microneedle electrodes for primary axillary hyperhidrosis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-5071","authenticated-orcid":false,"given":"S. B.","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Center International St. Mary's Hospital Catholic Kwandong University College of Medicine Incheon Korea"},{"name":"Kangskin Dermatology Clinic Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Center International St. Mary's Hospital Catholic Kwandong University College of Medicine Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Center International St. Mary's Hospital Catholic Kwandong University College of Medicine Incheon Korea"},{"name":"Department of Dermatology Yanbian University Hospital Yanji China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. H.","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Center International St. Mary's Hospital Catholic Kwandong University College of Medicine Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Center International St. Mary's Hospital Catholic Kwandong University College of Medicine Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.040"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34143.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4065\/80.5.657"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.09.011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354602"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2011.594056"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02339.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12260"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2017.1303168"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultras.2013.04.011"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12411"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16735"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12591","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12591","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T13:13:39Z","timestamp":1694697219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,23]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/srt.12591"],"URL":"https:\/\/doi.org\/10.1111\/srt.12591","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,23]]},"assertion":[{"value":"2018-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}