{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:25:08Z","timestamp":1782847508041,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["16\u201015\u201000248"],"award-info":[{"award-number":["16\u201015\u201000248"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>When laboratory animals are used one needs to anesthetize them before recording. However, the influence of anesthesia on animal blood flow oscillations has not been studied. The effects of two ways of anesthesia, zoletil\u2010xylazine, and zoletil\u2010nitrous oxide mixtures, on mouse skin perfusion using laser Doppler flowmetry (LDF<\/jats:styled-content>) technique were studied.<\/jats:p><\/jats:sec>Methods<\/jats:title>BALB<\/jats:styled-content>\/c mice were used. LDF<\/jats:styled-content> probe was placed on the ventral surface of the left hind paw. Spectral analysis of LDF<\/jats:styled-content> signals was performed with continuous adaptive wavelet transform to identify and describe peripheral blood flow oscillations in mouse skin.<\/jats:p><\/jats:sec>Results<\/jats:title>Low\u2010frequency oscillation interval boundaries (myogenic, neurogenic, and endothelial) for mice were shown to coincide with the boundaries determined for human and rats, that demonstrate their independence from the body size. Zoletil\u2010xylazine anesthesia significantly decreased neurogenic and endothelial oscillation amplitudes by 29% and 50% respectively and increased the amplitude of cardiac oscillations by 23% compared to zoletyl\u2010nitrous oxide anesthesia. There were no significant changes of the amplitudes of myogenic and respiratory oscillations with zoletil\u2010nitrous oxide anesthesia compared to the zoletil\u2010xylazine mixture.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We suggest that the different influence of anesthesia modes on the amplitudes of skin blood flow oscillations is associated with sympathetic activity suppressed by zoletil\u2010xylazine anesthesia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12593","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T09:24:51Z","timestamp":1527067491000},"page":"40-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Anesthesia effects on the low frequency blood flow oscillations in mouse skin"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6591-0748","authenticated-orcid":false,"given":"M. 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