{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:26:03Z","timestamp":1759814763583,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T00:00:00Z","timestamp":1539302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intralesional vincristine is an effective treatment for Kaposi's sarcoma (<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>) nodules on the skin, but there is little evidence of its action through imaging techniques. Ultrasonography can be an adjunctive tool in the diagnosis and management of <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> skin lesions, but data in the literature are few.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Five patients with classic <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> nodules were treated with intralesional vincristine. Ultrasonographic and color Doppler assessment were performed during vincristine injection and monitoring was repeated 1 and 3\u00a0months after the procedure. Partial response was defined as a reduction of more than 50% lesion volume and reduction of the vascular signal; complete response as a resolution of lesion associated with the absence of vascular signal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> nodules were included in the study. On ultrasonography examination, <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> nodules appeared as oval or round, hypoechoic, homogeneous structures, with intralesional vascularization, more prominent in the deepest pole of the nodule. At month 1, 4 nodules achieved a complete response, while two nodules showed a partial response and were retreated with intralesional vincristine. At month 3, all lesions achieved a complete response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ultrasonography may be a valuable tool in assessing clinical response to intralesional vincristine therapy of cutaneous <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> nodules.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12635","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T09:46:54Z","timestamp":1539337614000},"page":"200-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ultrasonographic intraoperative monitoring and follow\u2010up of Kaposi's sarcoma nodules under treatment with intralesional vincristine"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8534-6497","authenticated-orcid":false,"given":"Gianluca","family":"Nazzaro","sequence":"first","affiliation":[{"name":"Dipartimento di Fisiopatologia Medico\u2010Chirurgica e dei Trapianti Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"UOC Dermatologia Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7636-958X","authenticated-orcid":false,"given":"Giovanni","family":"Genovese","sequence":"additional","affiliation":[{"name":"Dipartimento di Fisiopatologia Medico\u2010Chirurgica e dei Trapianti Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"UOC Dermatologia Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasia","family":"Tourlaki","sequence":"additional","affiliation":[{"name":"Dipartimento di Fisiopatologia Medico\u2010Chirurgica e dei Trapianti Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"UOC Dermatologia Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Passoni","sequence":"additional","affiliation":[{"name":"Dipartimento di Fisiopatologia Medico\u2010Chirurgica e dei Trapianti Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"UOC Dermatologia Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Berti","sequence":"additional","affiliation":[{"name":"Dipartimento di Fisiopatologia Medico\u2010Chirurgica e dei Trapianti Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"UOC Dermatologia Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Dipartimento di Fisiopatologia Medico\u2010Chirurgica e dei Trapianti Universit\u00e0 degli Studi di Milano  Milan Italy"},{"name":"UOC Dermatologia Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.05.001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2012.31.1.97"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12586"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04047.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-199305000-00015"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-30-40"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2015.05.019"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91114-8"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19891215)64:12<2424::AID-CNCR2820641205>3.0.CO;2-X"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.1993.tb10397.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70010-Q"},{"key":"e_1_2_5_13_1","first-page":"E28","article-title":"Intralesional vinblastine injections for treatment of classic Kaposi sarcoma in diabetic patients","volume":"95","author":"Vassallo C","year":"2015","journal-title":"Cutis"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1978.01640230067019"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000249591"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09601.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.131.2.228b"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369490"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1684\/bdc.2012.1636"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2017.05.008"},{"key":"e_1_2_5_21_1","first-page":"83","article-title":"Staging of classic Kaposi's sarcoma: a useful tool for therapeutic choices","volume":"13","author":"Brambilla L","year":"2003","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2014.971698"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12635","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12635","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.12635","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12635","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T04:42:45Z","timestamp":1694407365000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,12]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/srt.12635"],"URL":"https:\/\/doi.org\/10.1111\/srt.12635","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"type":"print","value":"0909-752X"},{"type":"electronic","value":"1600-0846"}],"subject":[],"published":{"date-parts":[[2018,10,12]]},"assertion":[{"value":"2018-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}