{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T13:32:47Z","timestamp":1751981567052,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673085","81673047"],"award-info":[{"award-number":["81673085","81673047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"Abstract<\/jats:title>Background\/Aims<\/jats:title>How to select a suitable method in whitening products evaluation is still under discussion. Here, we compared two different artificial pigmentation models and explored an ideal UV<\/jats:styled-content> dosage for skin whitening products evaluation model establishment.<\/jats:p><\/jats:sec>Methods<\/jats:title>Thirty five healthy volunteers with type IV human skin were recruited and the skin minimal erythema dose (MED<\/jats:styled-content>s) and minimal persistent pigment dose (MPPD<\/jats:styled-content>s) were measured. All volunteers were simultaneously exposed to six increasing doses of radiations from different ultraviolet sources on lower back bilateral flattening area: 95% UVA<\/jats:styled-content>\/5% UVB<\/jats:styled-content> with the radiating doses of 0.75, 0.94, 1.17, 1.46, 1.83, 2.29 MED<\/jats:styled-content>s was used on the left side; meanwhile 99% UVA<\/jats:styled-content>\/1% UVB<\/jats:styled-content> with radiating doses of 6.0, 7.5, 9.4, 11.7, 14.6, 18.3 MPPD<\/jats:styled-content>s were used on the right side. Observations and pigmentation measurements were carried out before and after UV<\/jats:styled-content> radiation for 24\u00a0weeks.<\/jats:p><\/jats:sec>Result<\/jats:title>1.83 MED<\/jats:styled-content> and 2.29 MED<\/jats:styled-content> induced medium depth pigmentation by 95% UVA<\/jats:styled-content>\/5% UVB<\/jats:styled-content> irradiation. 1.83 MED<\/jats:styled-content> dose causing minimal photo\u2010damage on skin was selected as the most suitable dose. With 99% UVA<\/jats:styled-content>\/1% UVB<\/jats:styled-content> irradiation, 9.4 MPPD<\/jats:styled-content> and 11.7 MPPD<\/jats:styled-content> induced medium depth pigmentation. 9.4 MPPD<\/jats:styled-content> dose causing minimal photo\u2010damage on skin was selected.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These findings potentiate advanced understanding of UV<\/jats:styled-content> model establishment and selection for skin whitening products evaluation as related to dermatopharmacology and dermatotoxicology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12639","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T08:39:06Z","timestamp":1540456746000},"page":"204-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Minimal erythema dose, minimal persistent pigment dose which model for whitening products evaluation is better?"],"prefix":"10.1111","volume":"25","author":[{"given":"Xiangzi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010venereology The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"},{"name":"Department of Dermato\u2010venereology Shenzhen Centre for Chronic Disease Control and Prevention Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1847-2375","authenticated-orcid":false,"given":"Yue","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010venereology The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congxiu","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010venereology The Third Affiliated Hospital of Sun Yat\u2010sen University Guangzhou 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