{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:43:07Z","timestamp":1792154587627,"version":"4.4.0"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Amorepacific Co., Ltd"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Skin Research and Technology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Age\u2010related changes in lip morphological and physiological characteristics are key indices for estimating age based on facial features, as reported in many studies. Yet, a majority of studies have focused on Caucasian individuals, with few studies characterizing these changes in Asian female populations. Therefore, the aim of this study was to investigate lip morphological and physiological characteristics in a cohort of Korean women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 114 volunteers participated in the study. Linear distances (length of philtrum, length of lip, width of lip, and lengths of lower and upper oral commissures), angle of the upper lip, 3D lip heights, and wrinkles were calculated and averaged for each age\u2010group. We also measured lip color, hydration, trans\u2010epidermal water loss (<jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content>), and blood flow. Statistical analyses were performed using <jats:styled-content style=\"fixed-case\">SPSS<\/jats:styled-content> version 20.0 (significance level <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Length of the philtrum and lip width significantly increased with age while upper and lower lip lengths and length of the lower oral commissure significantly decreased with age. The angle of the upper lip tended to decrease with age, but this finding was no significance. Three\u2010dimensional height of the upper lip, wrinkles, and <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> also decreased with age while hydration increased with age. Finally, redness of the upper and lower lips as well as blood flow significantly decreased with age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Lips tended to shorten in length and widen with age, resulting in a thinner and longer appearance. With regard to physiological parameters, there were important age\u2010related changes in hydration and lip color.<\/jats:p><\/jats:sec>","DOI":"10.1111\/srt.12644","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T13:11:10Z","timestamp":1540473070000},"page":"277-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Age\u2010related changes in lip morphological and physiological characteristics in Korean women"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2108-4189","authenticated-orcid":false,"given":"Hyerim","family":"Kim","sequence":"first","affiliation":[{"name":"Skincare Division Amorepacific R&amp;D Center  Yongin Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8809-1434","authenticated-orcid":false,"given":"Myeongryeol","family":"Lee","sequence":"additional","affiliation":[{"name":"Skincare Division Amorepacific R&amp;D Center  Yongin Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Young","family":"Park","sequence":"additional","affiliation":[{"name":"Skincare Division Amorepacific R&amp;D Center  Yongin Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Min","family":"Kim","sequence":"additional","affiliation":[{"name":"The Clinical Trial Center for Bio\u2010Industry Semyung University  Jecheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyeon","family":"Han","sequence":"additional","affiliation":[{"name":"Skincare Division Amorepacific R&amp;D Center  Yongin Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Skincare Division Amorepacific R&amp;D Center  Yongin Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0294-1260(02)00129-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05741.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050453"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2009.04.013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008021"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000077838"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2007.00283.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02735.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12456"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-012-0063-7"},{"key":"e_1_2_7_12_1","first-page":"14","article-title":"Trouble of the lips every generation","volume":"9","author":"Tamura E","year":"2016","journal-title":"Fragrance J"},{"key":"e_1_2_7_13_1","first-page":"766","article-title":"Distributions of human lip mucosal melanocytes (in Japanese)","volume":"40","author":"Mitsuhashi Y","year":"1991","journal-title":"J Jpn Stomatol Soc"}],"container-title":["Skin Research and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsrt.12644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/srt.12644","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/srt.12644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T10:54:45Z","timestamp":1694343285000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/srt.12644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,25]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/srt.12644"],"URL":"https:\/\/doi.org\/10.1111\/srt.12644","archive":["Portico"],"relation":{},"ISSN":["0909-752X","1600-0846"],"issn-type":[{"value":"0909-752X","type":"print"},{"value":"1600-0846","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,25]]},"assertion":[{"value":"2018-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}